Sequencing peptides by electrospray ion-trap mass spectrometry: A useful tool in synthesis of Axinastatin 3
Abstract: Axinastatin 3 as a potential anticancer agent was synthesized by chemical methods. In an electrospray ion-trap mass spectrometer, using one stage of tandem mass spectrometry (MS/MS), the linear peptide intermediate was sequenced via the complementarities of y and b ions. Then, using multistep MS/MS (to MS6), the cyclic peptide was sequenced through sequentially removing one amino acid residue in each stage of MS/MS. The difference of the fragmentation mechanisms and the sequencing approaches between them is discussed.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Sequencing peptides by electrospray ion-trap mass spectrometry: A useful tool in synthesis of Axinastatin 3 ; volume:4 ; number:4 ; year:2006 ; pages:620-631 ; extent:12
Open chemistry ; 4, Heft 4 (2006), 620-631 (gesamt 12)
- Urheber
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Jia, Chenxi
Qi, Wei
He, Zhimin
Qiao, Bin
- DOI
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10.2478/s11532-006-0028-y
- URN
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urn:nbn:de:101:1-2410181537578.612002986520
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:37 MESZ
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Beteiligte
- Jia, Chenxi
- Qi, Wei
- He, Zhimin
- Qiao, Bin
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