Cardiac amyloidosis : evolving pathogenesis, multimodal diagnostics, and principles of treatment

Abstract: Amyloidosis is a protein deposition disorder in which insoluble fibril structures accumulate in the bodily tissues damaging the organ function. Cardiac amyloidosis is a severe but under-reported medical condition characterized by the accumulation of amyloid in the extracellular area of the myocardium, which results in thickening and stiffening of ventricular walls. Cardiac amyloidosis has recently gained much attention with its slowly surging incidence. With this study, we seek to comprehensively compile the pathophysiology and clinical picture of cardiac amyloidosis subtypes, extending a clinically oriented, up-to-date clinical approach to diagnosis and therapy. Cardiac amyloidosis can be caused by rare genetic mutations which may be inherited or acquired. The growing incidence can be attributed to advancements in imaging methods and other diagnostic modalities. Most occurrences of cardiac amyloidosis result from two forms of precursor protein: transthyretin [TTR] amyloid and immu.... https://www.excli.de/index.php/excli/article/view/6284

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Cardiac amyloidosis ; volume:22 ; year:2023 ; EXCLI journal ; 22 (2023)

Contributors, Places and Time

• Creator: Medarametla, Gnana Deepthi ; Kahlon, Ripudaman Singh ; Mahitha, Lampimukhi ; Shariff, Sanobar ; Vakkalagadda, Naga Praneeth ; Chopra, Hitesh ; Kamal, Mohammad Amjad ; Patel, Neil ; Sethi, Yashendra ; Kaka, Nirja

Further information

• DOI: 10.17179/excli2023-6284
• URN: urn:nbn:de:101:1-2023090803161966488705
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:46 AM CEST