Irreversible Bilateral Cicatricial Keratoconjunctivitis after Dupilumab Therapy

This report highlights a case of irreversible bilateral cicatricial keratoconjunctivitis related to dupilumab therapy for the treatment of severe atopic dermatitis (AD). After 38 years of AD, the patient began dupilumab therapy and achieved disease control. Two years into treatment, his ophthalmic examination was significant for bilateral cicatricial keratoconjunctivitis with severe foreshortening of the inferior conjunctival fornices, symblepharon, and ankyloblepharon, which persisted even after topical steroid eye drops and discontinuation of dupilumab. Treating dermatologists should be aware of this potential irreversible adverse effect, and we recommend that patients are monitored for ocular complications while on dupilumab therapy.

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
Irreversible Bilateral Cicatricial Keratoconjunctivitis after Dupilumab Therapy ; volume:13 ; number:2 ; year:2022 ; pages:638-642 ; extent:5
Case reports in ophthalmology ; 13, Heft 2 (2022), 638-642 (gesamt 5)

Creator
Nguyen, Minh T.
Tsukikawa, Mai
Lomazow, Whitney
Lee, Michele

DOI
10.1159/000525738
URN
urn:nbn:de:101:1-2022092201000878172985
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
15.08.2025, 7:30 AM CEST

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Associated

  • Nguyen, Minh T.
  • Tsukikawa, Mai
  • Lomazow, Whitney
  • Lee, Michele

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