Arterial spin labeling-based Z-maps have high specificity and positive predictive value for neurodegenerative dementia compared to FDG-PET
Abstract: Objective
Cerebral perfusion analysis based on arterial spin labeling (ASL) MRI has been proposed as an alternative to FDG-PET in patients with neurodegenerative disease. Z-maps show normal distribution values relating an image to a database of controls. They are routinely used for FDG-PET to demonstrate disease-specific patterns of hypometabolism at the individual level. This study aimed to compare the performance of Z-maps based on ASL to FDG-PET.
Methods
Data were combined from two separate sites, each cohort consisting of patients with Alzheimer’s disease (n = 18 + 7), frontotemporal dementia (n = 12 + 8) and controls (n = 9 + 29). Subjects underwent pseudocontinuous ASL and FDG-PET. Z-maps were created for each subject and modality. Four experienced physicians visually assessed the 166 Z-maps in random order, blinded to modality and diagnosis.
Results
Discrimination of patients versus controls using ASL-based Z-maps yielded high specificity (84%) and positive predictive value (80%), but significantly lower sensitivity compared to FDG-PET-based Z-maps (53% vs. 96%, p < 0.001). Among true-positive cases, correct diagnoses were made in 76% (ASL) and 84% (FDG-PET) (p = 0.168).
Conclusion
ASL-based Z-maps can be used for visual assessment of neurodegenerative dementia with high specificity and positive predictive value, but with inferior sensitivity compared to FDG-PET
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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European radiology. - 27, 10 (2017) , 4237-4246, ISSN: 0938-7994
- Event
-
Veröffentlichung
- (where)
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Freiburg
- (who)
-
Universität
- (when)
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2019
- Creator
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Fällmar, David
Haller, Sven
Lilja, Johanna
Danfors, Torsten
Kilander, Lena
Tolboom, Nelleke
Egger, Karl
Kellner, Elias
Croon, Philip M.
Verfaillie, Sander C. J.
Berckel, Bart N. M. van
Ossenkoppele, Rik
Barkhof, Frederik
Larsson, Elna-Marie
- Contributor
- DOI
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10.1007/s00330-017-4784-1
- URN
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urn:nbn:de:bsz:25-freidok-1416893
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:26 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Fällmar, David
- Haller, Sven
- Lilja, Johanna
- Danfors, Torsten
- Kilander, Lena
- Tolboom, Nelleke
- Egger, Karl
- Kellner, Elias
- Croon, Philip M.
- Verfaillie, Sander C. J.
- Berckel, Bart N. M. van
- Ossenkoppele, Rik
- Barkhof, Frederik
- Larsson, Elna-Marie
- Klinik für Radiologie
- Klinik für Neuroradiologie
- Universität
Time of origin
- 2019
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