Granulocyte macrophage colony-stimulating factor in allogenic hematopoietic stem cell transplantation: from graft-versus-host disease to the graft-versus-tumor effect
Abstract: Allogenic hematopoietic stem cell transplantation (allo-HSCT) is a widely used treatment for a broad range of hematologic malignancies because of its graft-versus-tumor (GVT) effect. Unfortunately, allo-HSCT is still associated with morbidity and mortality related to relapse and transplantation complications, namely graft-versus-host-disease (GVHD). In an era of therapies specifically targeting molecular pathways, transcription factors, and cytokines, a better understanding of GVHD physiopathology is essential for the development of new therapeutic approaches. In this review, we outline the current knowledge of the role of granulocyte- macrophage colony-stimulating factor (GM-CSF) in allo-HSCT. We first discuss the biology of GM-CSF and its signaling pathways, with a focus on the main producing cells, T cells. We discuss recent preclinical studies pointing to a pivotal role of GM-CSF in GVHD, in particular gastrointestinal GVHD. We then summarize the potential role of GM-CSF in the GVT effect, discussing some potential strategies for exploiting GM-CSF in the context of allo-HSCT
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Anmerkungen
-
Transplantation and cellular therapy. - 30, 4 (2024) , 386-395, ISSN: 2666-6367
- Ereignis
-
Veröffentlichung
- (wo)
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Freiburg
- (wer)
-
Universität
- (wann)
-
2024
- Urheber
- DOI
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10.1016/j.jtct.2024.01.060
- URN
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urn:nbn:de:bsz:25-freidok-2435548
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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25.03.2025, 13:55 MEZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
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Beteiligte
- Bernardi, Chiara
- Charvet, Céline
- Zeiser, Robert
- Simonetta, Federico
- Universität
Entstanden
- 2024
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