Epigenetic Reprogramming Potentiates ICAM1 Antibody Drug Conjugates in Preclinical Models of Melanoma
Abstract: Therapeutic benefits and underlying biomechanism (s) of antibody drug conjugates (ADC) in combination with other targeted therapeutics are largely unknown. Here, the synergy between ADC and epigenetic drug decitabine (DAC), a clinically approved DNA methylation inhibitor, in multiple preclinical models of melanoma specifically investigated. Mechanistically, the underlying biomechanisms of how DAC cooperatively worked with ICAM1 antibody conjugated DNA topoisomerase I inhibitor DXd (I1‐DXd) is elucidated. DAC treatment significantly enhanced anti‐tumor efficacy of I1‐DXd by upregulating antigen expression, enhancing antibody internalization and potentiating tumor sensitivity by epigenetically reprogramming of melanoma. Meanwhile, I1‐DXd/DAC combination also exerted regulatory effects on tumor microenvironment (TME) by enhancing tumor infiltration of innate and adaptive immune cells and improving penetration of ADCs with a boosted antitumor immunity. This study provides a rational ADC combination strategy for solid tumor treatment.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Epigenetic Reprogramming Potentiates ICAM1 Antibody Drug Conjugates in Preclinical Models of Melanoma ; day:14 ; month:06 ; year:2024 ; extent:19
Advanced science ; (14.06.2024) (gesamt 19)
- Creator
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Zhang, Peng
Tao, Changjuan
Lu, Ye
Li, Peijing
Wang, Xing
Dai, Yujie
Xi, Yun
Shimura, Takaya
Li, Xinfang
Fang, Jianmin
Yang, Liu
He, Dawei
Guo, Peng
- DOI
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10.1002/advs.202400203
- URN
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urn:nbn:de:101:1-2406151407407.283544485463
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:49 AM CEST
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Associated
- Zhang, Peng
- Tao, Changjuan
- Lu, Ye
- Li, Peijing
- Wang, Xing
- Dai, Yujie
- Xi, Yun
- Shimura, Takaya
- Li, Xinfang
- Fang, Jianmin
- Yang, Liu
- He, Dawei
- Guo, Peng
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