Functional divergence of gene duplicates through ectopic recombination
Gene duplication stimulates evolutionary innovation as the resulting paralogs acquire mutations that lead to sub‐ or neofunctionalization. A comprehensive in silico analysis of paralogs in Saccharomyces cerevisiae reveals that duplicates of cell‐surface and subtelomeric genes also undergo ectopic recombination, which leads to new chimaeric alleles. Mimicking such intergenic recombination events in the FLO (flocculation) family of cell‐surface genes shows that chimaeric FLO alleles confer different adhesion phenotypes than the parental genes. Our results indicate that intergenic recombination between paralogs can generate a large set of new alleles, thereby providing the raw material for evolutionary adaptation and innovation.
This report reveals that duplicated genes undergo ectopic recombination, which leads to new chimaeric alleles. Mimicking these intergenic recombination events creates chimaera with phenotypes that differ from those of their parental genes.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Functional divergence of gene duplicates through ectopic recombination ; volume:13 ; number:12 ; year:2012 ; pages:1145-1151 ; extent:7
EMBO reports / European Molecular Biology Organization ; 13, Heft 12 (2012), 1145-1151 (gesamt 7)
- Creator
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Christiaens, Joaquin F.
Van Mulders, Sebastiaan E.
Duitama, Jorge
Brown, Chris A.
Ghequire, Maarten G.
De Meester, Luc
Michiels, Jan
Wenseleers, Tom
Voordeckers, Karin
Verstrepen, Kevin J.
- DOI
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10.1038/embor.2012.157
- URN
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urn:nbn:de:101:1-2023030211183323271677
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 11:03 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Christiaens, Joaquin F.
- Van Mulders, Sebastiaan E.
- Duitama, Jorge
- Brown, Chris A.
- Ghequire, Maarten G.
- De Meester, Luc
- Michiels, Jan
- Wenseleers, Tom
- Voordeckers, Karin
- Verstrepen, Kevin J.
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