An Activatable Lanthanide Luminescent Probe for Time‐Gated Detection of Nitroreductase in Live Bacteria
Abstract: Herein we report the development of a turn‐on lanthanide luminescent probe for time‐gated detection of nitroreductases (NTRs) in live bacteria. The probe is activated through NTR‐induced formation of the sensitizing carbostyril antenna and resulting energy transfer to the lanthanide center. This novel NTR‐responsive trigger is virtually non‐fluorescent in its inactivated form and features a large signal increase upon activation. We show that the probe is capable of selectively sensing NTR in lysates as well as in live bacteria of the ESKAPE family which are clinically highly relevant multiresistant pathogens responsible for the majority of hospital infections. The results suggest that our probe could be used to develop diagnostic tools for bacterial infections.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
An Activatable Lanthanide Luminescent Probe for Time‐Gated Detection of Nitroreductase in Live Bacteria ; volume:59 ; number:22 ; year:2020 ; pages:8512-8516 ; extent:5
Angewandte Chemie / International edition. International edition ; 59, Heft 22 (2020), 8512-8516 (gesamt 5)
- Creator
- DOI
-
10.1002/anie.202002391
- URN
-
urn:nbn:de:101:1-2022061211341247034365
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:22 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Brennecke, Benjamin
- Wang, Qinghua
- Zhang, Qingyang
- Hu, Hai‐Yu
- Nazaré, Marc
Other Objects (12)
Luminescent properties of lanthanide dibenzoylmethide triethylammonium compounds
Lanthanide-doped luminescent nanomaterials : from fundamentals to bioapplications
Luminescent Lanthanide Probes for Inorganic and Organic Phosphates
Building blocks for multinuclear near-IR luminescent lanthanide complexes
Novel lanthanide-based luminescent probes for biological and lighting applications
Luminescent Lanthanide Complexes with Fluorinated Heterocycles as Light‐Harvesting Antennae
Activatable MRI probes for the specific detection of bacteria
Visualizing neuroinflammation with fluorescence and luminescent lanthanide-based in situ hybridization
Water: An Influential Agent for Lanthanide‐Doped Luminescent Nanoparticles in Nanomedicine
Luminescent lanthanide-doped nano- and microparticles and hybrid materials towards biomedical applications
Excited State Reservoir Computing using Hybrid Perovskite Electrochemically-Gated Luminescent Cells
Underestimated Color Centers: Defects as Useful Reducing Agents in Lanthanide‐Activated Luminescent Materials
Luminescent properties of lanthanide dibenzoylmethide triethylammonium compounds
Lanthanide-doped luminescent nanomaterials : from fundamentals to bioapplications
Luminescent Lanthanide Probes for Inorganic and Organic Phosphates
Building blocks for multinuclear near-IR luminescent lanthanide complexes
Novel lanthanide-based luminescent probes for biological and lighting applications
Luminescent Lanthanide Complexes with Fluorinated Heterocycles as Light‐Harvesting Antennae
Activatable MRI probes for the specific detection of bacteria
Visualizing neuroinflammation with fluorescence and luminescent lanthanide-based in situ hybridization
Water: An Influential Agent for Lanthanide‐Doped Luminescent Nanoparticles in Nanomedicine
Luminescent lanthanide-doped nano- and microparticles and hybrid materials towards biomedical applications
Excited State Reservoir Computing using Hybrid Perovskite Electrochemically-Gated Luminescent Cells
Underestimated Color Centers: Defects as Useful Reducing Agents in Lanthanide‐Activated Luminescent Materials
Luminescent properties of lanthanide dibenzoylmethide triethylammonium compounds
Lanthanide-doped luminescent nanomaterials : from fundamentals to bioapplications
Luminescent Lanthanide Probes for Inorganic and Organic Phosphates
Building blocks for multinuclear near-IR luminescent lanthanide complexes
Novel lanthanide-based luminescent probes for biological and lighting applications
Luminescent Lanthanide Complexes with Fluorinated Heterocycles as Light‐Harvesting Antennae
Activatable MRI probes for the specific detection of bacteria
Visualizing neuroinflammation with fluorescence and luminescent lanthanide-based in situ hybridization
Water: An Influential Agent for Lanthanide‐Doped Luminescent Nanoparticles in Nanomedicine
Luminescent lanthanide-doped nano- and microparticles and hybrid materials towards biomedical applications
Excited State Reservoir Computing using Hybrid Perovskite Electrochemically-Gated Luminescent Cells