Regulation of mesenchymal stem cell differentiation by autophagy
Abstract: Autophagy, a process that isolates intracellular components and fuses them with lysosomes for degradation, plays an important cytoprotective role by eliminating harmful intracellular substances and maintaining cellular homeostasis. Mesenchymal stem cells (MSCs) are multipotent progenitor cells with the capacity for self-renewal that can give rise to a subset of tissues and therefore have potential in regenerative medicine. However, a variety of variables influence the biological activity of MSCs following their proliferation and transplantation in vitro. The regulation of autophagy in MSCs represents a possible mechanism that influences MSC differentiation properties under the right microenvironment, affecting their regenerative and therapeutic potential. However, a deeper understanding of exactly how autophagy is mobilized to function as well as clarifying the mechanisms by which autophagy promotes MSCs differentiation is still needed. Here, we review the current literature on the complex link between MSCs differentiation and autophagy induced by various extracellular or intracellular stimuli and the molecular targets that influence MSCs lineage determination, which may highlight the potential regulation of autophagy on MSCs’ therapeutic capacity, and provide a broader perspective on the clinical application of MSCs in the treatment of a wide range of diseases.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Regulation of mesenchymal stem cell differentiation by autophagy ; volume:19 ; number:1 ; year:2024 ; extent:13
Open medicine ; 19, Heft 1 (2024) (gesamt 13)
- Creator
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Wei, Yanan
Zheng, Zejun
Zhang, Ying
Sun, Jinmeng
Xu, Shuangshuang
Di, Xinsheng
Ding, Xiaoling
Ding, Gang
- DOI
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10.1515/med-2024-0968
- URN
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urn:nbn:de:101:1-2405221535371.156685842692
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:49 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Wei, Yanan
- Zheng, Zejun
- Zhang, Ying
- Sun, Jinmeng
- Xu, Shuangshuang
- Di, Xinsheng
- Ding, Xiaoling
- Ding, Gang
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