First Reported Case of Atypical Meningioma in an Individual with Down Syndrome

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Individuals with Down syndrome are at decreased risk of developing most types of solid tumors, including central nervous system malignancies. Several mechanisms have been proposed to explain how additional genetic material on chromosome 21 may confer this increased protection. Only two individuals with Down syndrome and meningioma have been described in the medical literature, whose tumors were both World Health Organization (WHO) grade 1. Here, we report the first individual with Down syndrome to our knowledge who developed an atypical meningioma, WHO grade 2. We also provide a hypothesis for how this tumor could have arisen in the setting of trisomy 21.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
First Reported Case of Atypical Meningioma in an Individual with Down Syndrome ; volume:14 ; number:1 ; year:2022 ; pages:191-196 ; extent:6
Case reports in neurology ; 14, Heft 1 (2022), 191-196 (gesamt 6)

Urheber
Vanderschelden, Rachel
Golshani, Kiarash
Evans, Mark G.

DOI
10.1159/000523665
URN
urn:nbn:de:101:1-2022051200574670693025
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:38 MESZ

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Beteiligte

  • Vanderschelden, Rachel
  • Golshani, Kiarash
  • Evans, Mark G.

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