Thrombotic Microangiopathy Associated with Gemcitabine in Non-Small Cell Lung Cancer: A Case Report

A 69-year-old man with refractory lung adenocarcinoma was treated with gemcitabine and vinorelbine. Dyspnea and hypertension developed after the 17th cycle of chemotherapy. Laboratory findings revealed intravascular hemolysis and renal dysfunction. Thrombotic microangiopathy (TMA) was confirmed by renal biopsy. Antihypertensive and steroid therapies were ineffective. After plasmapheresis, intravascular hemolysis and renal dysfunction gradually improved. However, the disease progressed, and he died 6 months after TMA diagnosis. Autopsy revealed similar pathological findings to those of the renal biopsy. It is important to discontinue gemcitabine at the onset of TMA and consider TMA when using gemcitabine for long periods.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Thrombotic Microangiopathy Associated with Gemcitabine in Non-Small Cell Lung Cancer: A Case Report ; volume:14 ; number:3 ; year:2021 ; pages:1712-1718 ; extent:7 ; Case reports in oncology ; 14, Heft 3 (2021), 1712-1718 (gesamt 7)

Contributors, Places and Time

• Creator: Kuribayashi, Tadahiro ; Fujiwara, Keiichi ; Onishi, Kiriko ; Mitsumune, Sho ; Takigawa, Yuki ; Watanabe, Hiromi ; Kudo, Kenichiro ; Sato, Akiko ; Sato, Ken ; Kitagawa, Masashi ; Ota, Kosuke ; Shinno, Yoko ; Shibayama, Takuo

Further information

• DOI: 10.1159/000520484
• URN: urn:nbn:de:101:1-2022011223342639182922
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:32 AM CEST