Prophylaxis and treatment of infection in long bones using an antibiotic-loaded ceramic coating with interlocking intramedullary nails

Abstract Background 24/24 patients) prevention of infection rate, 95.5 % union rate (21/22 patients), and 100 % (24/24  patients) limb salvage rate. Nine patients were treated with CS-IMN to eradicate infection and were compared to a cohort of 28 patients who were treated with PMMA-IMN. The infection was eradicated in 7/9 patients (77.8 %) in the CS-IMN group versus 21/26 patients (80 %) in the PMMA-IMN group (p = 0.44). Bone union/fusion was achieved in 8/9 patients (88.9 %) in the CS-IMN group versus 21/24 patients (87.5 %) in the PMMA-IMN group (p = 0.11). The limb salvage rate in the CS-IMN group was 100 % (9/9  patients) versus 89 % (25/28  patients) in the PMMA-IMN group. Conclusions: CS-IMN are safe and easy to use, and we have therefore expended our indications for them. CS-IMN are very effective at infection prophylaxis in high-risk cases where infection is suspected. Early analysis suggests that CS-IMN are non-inferior to PMMA-IMN for infection eradication. This is our preliminary data that show this novel technique to be safe in a small cohort and may be as effective as the more established method. Future studies with larger cohorts of patients will be required to confirm these findings.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Prophylaxis and treatment of infection in long bones using an antibiotic-loaded ceramic coating with interlocking intramedullary nails ; volume:7 ; number:2 ; year:2022 ; pages:101-107 ; extent:7 ; Journal of bone and joint infection ; 7, Heft 2 (2022), 101-107 (gesamt 7)

Contributors, Places and Time

• Creator: Downey, Emilie-Ann ; Jaime, Kayla M. ; Reif, Taylor J. ; Makhdom, Asim M. ; Rozbruch, S. Robert ; Fragomen, Austin T.

Further information

• DOI: 10.5194/jbji-7-101-2022
• URN: urn:nbn:de:101:1-2022042805290708832807
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:21 AM CEST