Alveolar Microdynamics during Tidal Ventilation in Live Animals Imaged by SPring‐8 Synchrotron

Abstract: It is self‐evident that our chests expand and contract during breathing but, surprisingly, exactly how individual alveoli change shape over the respiratory cycle is still a matter of debate. Some argue that all the alveoli expand and contract rhythmically. Others claim that the lung volume change is due to groups of alveoli collapsing and reopening during ventilation. Although this question might seem to be an insignificant detail for healthy individuals, it might be a matter of life and death for patients with compromised lungs. Past analyses were based on static post‐mortem preparations primarily due to technological limitations, and therefore, by definition, incapable of providing dynamic information. In contrast, this study provides the first comprehensive dynamic data on how the shape of the alveoli changes, and, further, provides valuable insights into the optimal lung volume for efficient gas exchange. It is concluded that alveolar micro‐dynamics is nonlinear; and at medium lung volume, alveoli expand more than the ducts.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Alveolar Microdynamics during Tidal Ventilation in Live Animals Imaged by SPring‐8 Synchrotron ; day:03 ; month:07 ; year:2024 ; extent:14 ; Advanced science ; (03.07.2024) (gesamt 14)

Contributors, Places and Time

• Creator: Kim, Min Woo ; Yu, Seung Hyeon ; Yang, Un ; Nukiwa, Ryota ; Cho, Hyeon Jung ; Kwon, Nam Seop ; Yong, Moon Jung ; Kim, Nam Ho ; Lee, Sang Hyeon ; Lee, Jun Ho ; Lim, Jae Hong ; Kohmura, Yoshiki ; Ishikawa, Tatsuya ; Henry, Frank S. ; Imai, Yumiko ; Oh, Seung Soo ; Hwang, Hyung Ju ; Tsuda, Akira ; Je, Jung Ho

Further information

• DOI: 10.1002/advs.202306256
• URN: urn:nbn:de:101:1-2407081417196.658105468085
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:53 AM CEST