Tough Gelatin Hydrogel for Tissue Engineering
Abstract: Tough hydrogel has attracted considerable interest in various fields, however, due to poor biocompatibility, nondegradation, and pronounced compositional differences from natural tissues, it is difficult to be used for tissue regeneration. Here, a gelatin‐based tough hydrogel (GBTH) is proposed to fill this gap. Inspired by human exercise to improve muscle strength, the synergistic effect is utilized to generate highly functional crystalline domains for resisting crack propagation. The GBTH exhibits excellent tensile strength of 6.67 MPa (145‐fold that after untreated gelation). Furthermore, it is directly sutured to a ruptured tendon of adult rabbits due to its pronounced toughness and biocompatibility, self‐degradability in vivo, and similarity to natural tissue components. Ruptured tendons can compensate for mechanotransduction by GBTH and stimulate tendon differentiation to quickly return to the initial state, that is, within eight weeks. This strategy provides a new avenue for preparation of highly biocompatible tough hydrogel for tissue regeneration.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Tough Gelatin Hydrogel for Tissue Engineering ; day:23 ; month:06 ; year:2023 ; extent:16
Advanced science ; (23.06.2023) (gesamt 16)
- Urheber
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Yuan, Ximin
Zhu, Zhou
Xia, Pengcheng
Wang, Zhenjia
Zhao, Xiao
Jiang, Xiao
Wang, Tianming
Gao, Qing
Xu, Jie
Shan, Debin
Guo, Bin
Yao, Qingqiang
He, Yong
- DOI
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10.1002/advs.202301665
- URN
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urn:nbn:de:101:1-2023062415040320555505
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 11:03 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Yuan, Ximin
- Zhu, Zhou
- Xia, Pengcheng
- Wang, Zhenjia
- Zhao, Xiao
- Jiang, Xiao
- Wang, Tianming
- Gao, Qing
- Xu, Jie
- Shan, Debin
- Guo, Bin
- Yao, Qingqiang
- He, Yong
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