Novel Ionizable Lipid Nanoparticles for SARS‐CoV‐2 Omicron mRNA Delivery
Abstract: mRNA‐based therapy has emerged as the most promising nucleic acid therapy in the fight against COVID‐19. However, a safe and efficacious systemic delivery remains a challenge for mRNA therapy. Lipid nanoparticles (LNPs) are currently widely used in mRNA delivery vehicles. Here, a series of ionizable LNPs is rationally designed. YK009‐LNP is an optimal delivery platform to carry mRNA. YK009‐LNP exhibits higher mRNA delivery efficiency, a more favorable biodistribution pattern, and better safety than the approved MC3‐LNP. In addition, mRNA encoding severe acute respiratory syndrome coronavirus 2 Omicron receptor binding domain protein is synthesized and intramuscular administration of mice with YK009‐LNP‐Omicron mRNA induces a robust immune response and immune protective effect. A novel mRNA delivery vehicle with more powerful delivery efficiency and better safety than the approved LNPs is provided here.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Novel Ionizable Lipid Nanoparticles for SARS‐CoV‐2 Omicron mRNA Delivery ; day:17 ; month:02 ; year:2023 ; extent:14
Advanced healthcare materials ; (17.02.2023) (gesamt 14)
- Creator
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Long, Jinrong
Yu, Changxiao
Zhang, Honglei
Cao, Yiming
Sang, Ye
Lu, Haitao
Zhang, Zhen
Wang, Xin
Wang, Huanyu
Song, Gengshen
Yang, Jing
Wang, Shengqi
- DOI
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10.1002/adhm.202202590
- URN
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urn:nbn:de:101:1-2023021814104508447577
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:46 AM CEST
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Associated
- Long, Jinrong
- Yu, Changxiao
- Zhang, Honglei
- Cao, Yiming
- Sang, Ye
- Lu, Haitao
- Zhang, Zhen
- Wang, Xin
- Wang, Huanyu
- Song, Gengshen
- Yang, Jing
- Wang, Shengqi
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