Epidemiology and biology of early onset colorectal cancer
Abstract: Colorectal cancer (CRC) is the third leading cause of cancer-related mortality in men or women in the United States. Average-risk screening that begins at age 50 years has reduced incidence and mortality of CRC in those over 50 years of age, whereas CRC incidence in those under age 50 years (early onset colorectal cancer (eoCRC)) has recently and dramatically increased. In this review, we summarize the recent literature including risk factors for eoCRC, differences in clinicopathologic presentation and outcomes in eoCRC, and emerging evidence regarding the molecular pathways that are altered in eoCRC compared to later onset CRC (loCRC). Epidemiologic studies of eoCRC show predominance in distal colon and rectum, and association with several modifiable risk factors, including diabetes, obesity, diet, sedentary time, alcohol consumption and smoking. Data regarding potential risk factors of prior antibiotic exposure and microbiome alterations or direct carcinogen exposure are still em.... https://www.excli.de/index.php/excli/article/view/4456
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Epidemiology and biology of early onset colorectal cancer ; volume:21 ; day:07 ; month:01 ; year:2022
EXCLI journal ; 21 (07.01.2022)
- Creator
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Venugopal, Anand
Carethers, John M.
- DOI
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10.17179/excli2021-4456
- URN
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urn:nbn:de:101:1-2022020402131830529137
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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16.08.2025, 6:10 PM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Venugopal, Anand
- Carethers, John M.
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