The bovine dialyzable leukocyte extract, immunepotent CRP, synergically enhances cyclophosphamide-induced breast cancer cell death, through a caspase-independent mechanism
Abstract: Breast cancer (BC) is one of the leading causes of cancer death worldwide. Cyclophosphamide (CTX) remains a mainstay in cancer therapy despite harmful adverse effects and cell death-resistances. To face this, combinational therapy of chemotherapies and immunotherapies has been proposed. IMMUNEPOTENT CRP (ICRP) is an immunotherapy that has cytotoxic effects in several cancer cells without affecting peripheral blood mononuclear cells (PBMC) and CD3+ cells. The aim of this study was to evaluate cytotoxicity, the type of cytotoxic effect, and several features involved in cell death induced by the combination of CTX with ICRP (ICRP+CTX) in breast cancer cells as well as their effect on healthy cells. For this purpose, human and murine breast cancer cells, MCF-7, MDA-MB-231 and 4T1, or PBMC were treated for 24 hours with ICRP, CTX or ICRP+CTX in different combination ratios for the assessment of cell death. Flow cytometry and microscopy were used to determine biochemical and morphologica.... https://www.excli.de/index.php/excli/article/view/5389
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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The bovine dialyzable leukocyte extract, immunepotent CRP, synergically enhances cyclophosphamide-induced breast cancer cell death, through a caspase-independent mechanism ; volume:22 ; year:2023
EXCLI journal ; 22 (2023)
- Creator
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Rivera-Lazarín, Ana Luisa
Martinez-Torres, Ana Carolina
de la Hoz-Camacho, Rafael
Guzmán-Aguillón, Olga Liliana
Franco-Molina, Moisés Armides
Rodríguez-Padilla, Cristina
- DOI
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10.17179/excli2022-5389
- URN
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urn:nbn:de:101:1-2023012702141394400861
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:20 AM CEST
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Associated
- Rivera-Lazarín, Ana Luisa
- Martinez-Torres, Ana Carolina
- de la Hoz-Camacho, Rafael
- Guzmán-Aguillón, Olga Liliana
- Franco-Molina, Moisés Armides
- Rodríguez-Padilla, Cristina
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Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival
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Changes in levels of BNP, CRP and leukocyte formula during exercise testing in patients with dilated cardiomyopathy
Adenoviral delivery of pan-caspase inhibitor p35 enhances bystander killing by P450 gene-directed enzyme prodrug therapy using cyclophosphamide+
Ausgabe der 'CRP Information'
Development of a fast and economical genotyping protocol for bovine leukocyte adhesion deficiency (BLAD) in cattle
Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis
IMMUNEPOTENT CRP induces cell cycle arrest and caspase-independent regulated cell death in HeLa cells through reactive oxygen species production
Endonuclease G takes part in AIF-mediated caspase-independent apoptosis in Mycobacterium bovis-infected bovine macrophages
Examination of the bovine leukocyte environment using immunogenetic biomarkers to assess immunocompetence following exposure to weaning stress
Ethyl pyruvate reduces systemic leukocyte activation via Caspase-1 and NF-κB after blunt chest trauma and haemorrhagic shock
CRP-Verlauf nach dorsaler Spondylodese
Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival
The effect of APN, hs-CRP and APN/hs-CRP in periodontitis with DAA
Changes in levels of BNP, CRP and leukocyte formula during exercise testing in patients with dilated cardiomyopathy
Adenoviral delivery of pan-caspase inhibitor p35 enhances bystander killing by P450 gene-directed enzyme prodrug therapy using cyclophosphamide+
Ausgabe der 'CRP Information'
Development of a fast and economical genotyping protocol for bovine leukocyte adhesion deficiency (BLAD) in cattle
Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis
IMMUNEPOTENT CRP induces cell cycle arrest and caspase-independent regulated cell death in HeLa cells through reactive oxygen species production
Endonuclease G takes part in AIF-mediated caspase-independent apoptosis in Mycobacterium bovis-infected bovine macrophages
Examination of the bovine leukocyte environment using immunogenetic biomarkers to assess immunocompetence following exposure to weaning stress
Ethyl pyruvate reduces systemic leukocyte activation via Caspase-1 and NF-κB after blunt chest trauma and haemorrhagic shock
CRP-Verlauf nach dorsaler Spondylodese
Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival