Gene Delivery to Nonhuman Primate Preimplantation Embryos Using Recombinant Adeno‐Associated Virus

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Abstract: Delivery of genome editing tools to mammalian zygotes has revolutionized animal modeling. However, the mechanical delivery method to introduce genes and proteins to zygotes remains a challenge for some animal species that are important in biomedical research. Here, an approach to achieve gene delivery and genome editing in nonhuman primate embryos is presented by infecting zygotes with recombinant adeno‐associated viruses (rAAVs). Together with previous reports from the authors of this paper and others, this approach is potentially applicable to a broad range of mammals. In addition to genome editing and animal modeling, this rAAV‐based method can facilitate gene function studies in early‐stage embryos.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Gene Delivery to Nonhuman Primate Preimplantation Embryos Using Recombinant Adeno‐Associated Virus ; volume:6 ; number:21 ; year:2019 ; extent:6
Advanced science ; 6, Heft 21 (2019) (gesamt 6)

Urheber
Wang, Dan
Niu, Yuyu
Ren, Lingzhi
Kang, Yu
Tai, Phillip W. L.
Si, Chenyang
Mendonca, Craig A.
Ma, Hong
Gao, Guangping
Ji, Weizhi

DOI
10.1002/advs.201900440
URN
urn:nbn:de:101:1-2022072509522318225136
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:38 MESZ

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Beteiligte

  • Wang, Dan
  • Niu, Yuyu
  • Ren, Lingzhi
  • Kang, Yu
  • Tai, Phillip W. L.
  • Si, Chenyang
  • Mendonca, Craig A.
  • Ma, Hong
  • Gao, Guangping
  • Ji, Weizhi

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