Endoscopic vacuum-assisted closure therapy for leakage of the lower gastrointestinal tract: multicenter experiences
Abstract: Background and study aims Only a few studies are available regarding endoscopic vacuum-assisted closure (E-VAC) therapy for the post-surgery leakage of the lower gastrointestinal tract. Patients and methods In this multicenter German study, we retrospectively analyzed patients treated with E-VAC therapy due to post-surgery leakage of the lower gastrointestinal tract from 2000–2020 at Hannover Medical School, University Medical Center Schleswig-Holstein, Campus Luebeck, and Robert Koch Hospital Gehrden. Results Overall, 147 patients were included in this study. Most patients had undergone tumor resections of the lower gastrointestinal tract (n = 88; 59.9 %). Median time to diagnosis of leakage was 10 days (interquartile range [IQR] 6–19). Median duration of E-VAC therapy was 14 days (IQR 8–27). Increase of C-reactive protein (CRP) levels significantly correlated with first diagnosis of leakage (P 100 mg/L (78.4 % vs. 52.7 %; P = 0.012). Odds ratio for failure of stoma reversal was 3.36 in cases with CRP values > 100 mg/L (P = 0.017). In total, leakage- and/or E-VAC therapy-associated complications occurred in 26 patients (17.7 %). Minor complications included recurrent E-VAC dislocations and subsequent stenosis. Overall, 14 leakage- or E-VAC-associated deaths were observed most often due to sepsis. Conclusions E-VAC therapy due to post-surgery leakage of the lower gastrointestinal tract is safe and effective. High levels of CRP are a negative predictor of E-VAC therapy success.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Endoscopic vacuum-assisted closure therapy for leakage of the lower gastrointestinal tract: multicenter experiences ; volume:11 ; number:02 ; year:2023 ; pages:E212-E217
Endoscopy International Open ; 11, Heft 02 (2023), E212-E217
- Contributor
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Book, Thorsten
Engelke, Carsten
Brüggerhoff, Raphael
Winny, Markus
Kraus, Martin
Benecke, Claudia
Zimmermann, Markus
Trostdorf, Ulf
Wedemeyer, Heiner
Marquardt, Jens U.
Voigtländer, Torsten
Wedemeyer, Jochen
Kirstein, Martha M.
- DOI
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10.1055/a-1990-0392
- URN
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urn:nbn:de:101:1-2023041310190632449213
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:53 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Book, Thorsten
- Engelke, Carsten
- Brüggerhoff, Raphael
- Winny, Markus
- Kraus, Martin
- Benecke, Claudia
- Zimmermann, Markus
- Trostdorf, Ulf
- Wedemeyer, Heiner
- Marquardt, Jens U.
- Voigtländer, Torsten
- Wedemeyer, Jochen
- Kirstein, Martha M.
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