The critical role of adrenomedullin and its binding protein, AMBP-1, in neuroprotection
Abstract: Chronic neurodegenerative disorders and acute injuries of the central nervous system exert a prohibitive economic burden, which is aggravated by an unmet medical need for the development of effective neurotherapeutics. The evolutionarily conserved neuropeptide, adrenomedullin (AM), and its binding protein, AMBP-1, also known as complement factor H, play important roles in brain physiology, and their expression is altered in brain pathology. In this review, we discuss the molecular regulation of AM and AMBP-1 and the pivotal roles they play in neuroprotection following brain injury. We assess the reciprocal synergistic effects of AM and AMBP-1 and make suggestions for the design of a novel combination neurotherapy devoid of the potential hypotensive effects of AM while optimizing its neuroprotective property.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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The critical role of adrenomedullin and its binding protein, AMBP-1, in neuroprotection ; volume:393 ; number:6 ; year:2012 ; pages:429-439
Biological chemistry ; 393, Heft 6 (2012), 429-439
- Urheber
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Cheyuo, Cletus
Yang, Weng-Lang
Wang, Ping
- DOI
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10.1515/hsz-2012-0103
- URN
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urn:nbn:de:101:1-2408051704109.513816779008
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 11:03 MESZ
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Beteiligte
- Cheyuo, Cletus
- Yang, Weng-Lang
- Wang, Ping
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