Metabolomic analysis-identified 2-hydroxybutyric acid might be a key metabolite of severe preeclampsia

Abstract: This study set out to determine the key metabolite changes underlying the pathophysiology of severe preeclampsia (PE) using metabolic analysis. We collected sera from 10 patients with severe PE and from 10 healthy pregnant women of the same trimester and analyzed them using liquid chromatography mass spectrometry. A total of 3,138 differential metabolites were screened, resulting in the identification of 124 differential metabolites. Kyoto encyclopedia of genes and genomes pathway analysis revealed that they were mainly enriched in the following metabolic pathways: central carbon metabolism in cancer; protein digestion and absorption; aminoacyl-transfer RNA biosynthesis; mineral absorption; alanine, aspartate, and glutamate metabolism; and prostate cancer. After analysis of 124 differential metabolites, 2-hydroxybutyric acid was found to be the most critical differential metabolite, and its use allowed the differentiation of women with severe PE from healthy pregnant women. In summary, our analysis revealed that 2-hydroxybutyric acid is a potential key metabolite for distinguishing severe PE from healthy controls and is also a marker for the early diagnosis of severe PE, thus allowing early intervention.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Metabolomic analysis-identified 2-hydroxybutyric acid might be a key metabolite of severe preeclampsia ; volume:18 ; number:1 ; year:2023 ; extent:11 ; Open life sciences ; 18, Heft 1 (2023) (gesamt 11)

Beteiligte, Orts- und Zeitangaben

• Urheber: Wang, Fang ; Xu, Lili ; Qi, Mingming ; Lai, Huimin ; Zeng, Fanhua ; Liang, Furong ; Wen, Qing ; Ma, Xihua ; Zhang, Chan ; Xie, Kaili

Weitere Informationen

• DOI: 10.1515/biol-2022-0572
• URN: urn:nbn:de:101:1-2023022813193214078700
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:58 MESZ