Radiation‐Sensitive Dendrimer‐Based Drug Delivery System

Abstract: Combination of chemotherapy and radiotherapy is used to enhance local drug delivery while reducing off‐target tissue effects. Anticancer drug doxorubicin (DOX) is loaded into l‐cysteine modified G4.5 dendrimer (GC/DOX) and released at different pH values in the presence and absence of γ‐radiation. Presence of γ‐radiation significantly improves DOX release from the GC/DOX under acidic pH conditions, suggesting that GC dendrimer is a radiation‐sensitive drug delivery system. GC/DOX is further evaluated by determining cytotoxicity in uterine cervical carcinoma HeLa cells. GC/DOX shows high affinity for cancer cells and effective drug release following an external stimulus (radiation exposure), whereas an in vivo zebrafish study confirms that l‐cysteine acts as a radiosensitizer. GC/DOX treatment combined with radiotherapy synergistically and successfully inhibits cancer cell growth.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Radiation‐Sensitive Dendrimer‐Based Drug Delivery System ; volume:5 ; number:2 ; year:2018 ; extent:13 ; Advanced science ; 5, Heft 2 (2018) (gesamt 13)

Beteiligte, Orts- und Zeitangaben

• Urheber: Wu, Szu‐Yuan ; Chou, Hsiao‐Ying ; Yuh, Chiou‐Hwa ; Mekuria, Shewaye Lakew ; Kao, Yu‐Chih ; Tsai, Hsieh‐Chih

Weitere Informationen

• DOI: 10.1002/advs.201700339
• URN: urn:nbn:de:101:1-2022082609330486147957
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:39 MESZ