Phase Separation in Kidney Diseases: Autosomal Dominant Polycystic Kidney Disease and Beyond
Background: The formation of biomolecular condensates via phase separation has emerged as a fundamental principle underlying the spatiotemporal coordination of biological activities in cells. Aberrant biomolecular condensates often directly regulate key cellular process involved in the pathogenesis of human diseases, including kidney diseases. Summary: In this review, we summarize the physiological roles of phase separation and methodologies for phase separation studies. Taking autosomal dominant polycystic kidney disease as an example, we discuss recent advances toward elucidating the multiple mechanisms involved in kidney pathology arising from aberrant phase separation. We suggest that dysregulation of phase separation contributes to the pathogenesis of other important kidney diseases, including kidney injury and fibrosis. Key Messages: Phase separation provides a useful new concept to understand the mechanisms underlying kidney disease development. Targeting aberrant phase-separated condensates offers new therapeutic avenues for combating kidney diseases.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Phase Separation in Kidney Diseases: Autosomal Dominant Polycystic Kidney Disease and Beyond ; volume:9 ; number:4 ; year:2023 ; pages:229-238 ; extent:10
Kidney diseases ; 9, Heft 4 (2023), 229-238 (gesamt 10)
- Urheber
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Zhang, Lirong
Liu, Zhiheng
Lu, Yumei
Nie, Jing
Chen, Yupeng
- DOI
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10.1159/000530250
- URN
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urn:nbn:de:101:1-2023083100193351791256
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:54 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Zhang, Lirong
- Liu, Zhiheng
- Lu, Yumei
- Nie, Jing
- Chen, Yupeng
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