Inducin Triggers LC3‐Lipidation and ESCRT‐Mediated Lysosomal Membrane Repair

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Abstract: Lipidation of the LC3 protein has frequently been employed as a marker of autophagy. However, LC3‐lipidation is also triggered by stimuli not related to canonical autophagy. Therefore, characterization of the driving parameters for LC3 lipidation is crucial to understanding the biological roles of LC3. We identified a pseudo‐natural product, termed Inducin, that increases LC3 lipidation independently of canonical autophagy, impairs lysosomal function and rapidly recruits Galectin 3 to lysosomes. Inducin treatment promotes Endosomal Sorting Complex Required for Transport (ESCRT)‐dependent membrane repair and transcription factor EB (TFEB)‐dependent lysosome biogenesis ultimately leading to cell death.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Inducin Triggers LC3‐Lipidation and ESCRT‐Mediated Lysosomal Membrane Repair ; day:07 ; month:11 ; year:2023 ; extent:12
ChemBioChem ; (07.11.2023) (gesamt 12)

Creator: Corkery, Dale
Ursu, Andrei
Lucas, Belén
Grigalunas, Michael
Kriegler, Simon
Oliva, Rosario
Dec, Robert
Koska, Sandra
Pahl, Axel
Sievers, Sonja
Ziegler, Slava
Winter, Roland
Wu, Yaowen
Waldmann, Herbert

DOI: 10.1002/cbic.202300579

URN: urn:nbn:de:101:1-2023110814100121448268

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:48 AM CEST

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Associated

Corkery, Dale
Ursu, Andrei
Lucas, Belén
Grigalunas, Michael
Kriegler, Simon
Oliva, Rosario
Dec, Robert
Koska, Sandra
Pahl, Axel
Sievers, Sonja
Ziegler, Slava
Winter, Roland
Wu, Yaowen
Waldmann, Herbert

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mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane permeabilization-mediated autophagy

MLKL polymerization-induced lysosomal membrane permeabilization promotes necroptosis

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

Annexin A7 is required for ESCRT III-mediated plasma membrane repair

Mitochondrial translation deficiency impairs NAD + ‐mediated lysosomal acidification

Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization

Mucopolysaccharidosis IIIB, a lysosomal storage disease, triggers a pathogenic CNS autoimmune response

TFEB-mediated lysosomal biogenesis and lysosomal drug sequestration confer resistance to MEK inhibition in pancreatic cancer

An increase of lysosomes through EGF-triggered endocytosis attenuated zinc-mediated lysosomal membrane permeabilization and neuronal cell death

The Wae to repair: prostaglandin E2 (PGE 2) triggers intestinal wound repair

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mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane permeabilization-mediated autophagy

MLKL polymerization-induced lysosomal membrane permeabilization promotes necroptosis

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

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Mitochondrial translation deficiency impairs NAD + ‐mediated lysosomal acidification

Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization

Mucopolysaccharidosis IIIB, a lysosomal storage disease, triggers a pathogenic CNS autoimmune response

TFEB-mediated lysosomal biogenesis and lysosomal drug sequestration confer resistance to MEK inhibition in pancreatic cancer

An increase of lysosomes through EGF-triggered endocytosis attenuated zinc-mediated lysosomal membrane permeabilization and neuronal cell death

The Wae to repair: prostaglandin E2 (PGE 2) triggers intestinal wound repair

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Inducin Triggers LC3‐Lipidation and ESCRT‐Mediated Lysosomal Membrane Repair

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Other Objects (12)

Methylmalonic acidemia triggers lysosomal-autophagy dysfunctions

mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane permeabilization-mediated autophagy

MLKL polymerization-induced lysosomal membrane permeabilization promotes necroptosis

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

Annexin A7 is required for ESCRT III-mediated plasma membrane repair

Annexin A7 is required for ESCRT III-mediated plasma membrane repair

Mitochondrial translation deficiency impairs NAD + ‐mediated lysosomal acidification

Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization

Mucopolysaccharidosis IIIB, a lysosomal storage disease, triggers a pathogenic CNS autoimmune response

TFEB-mediated lysosomal biogenesis and lysosomal drug sequestration confer resistance to MEK inhibition in pancreatic cancer

An increase of lysosomes through EGF-triggered endocytosis attenuated zinc-mediated lysosomal membrane permeabilization and neuronal cell death

The Wae to repair: prostaglandin E2 (PGE 2) triggers intestinal wound repair

Methylmalonic acidemia triggers lysosomal-autophagy dysfunctions

mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane permeabilization-mediated autophagy

MLKL polymerization-induced lysosomal membrane permeabilization promotes necroptosis

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

Annexin A7 is required for ESCRT III-mediated plasma membrane repair

Annexin A7 is required for ESCRT III-mediated plasma membrane repair

Mitochondrial translation deficiency impairs NAD + ‐mediated lysosomal acidification

Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization

Mucopolysaccharidosis IIIB, a lysosomal storage disease, triggers a pathogenic CNS autoimmune response

TFEB-mediated lysosomal biogenesis and lysosomal drug sequestration confer resistance to MEK inhibition in pancreatic cancer

An increase of lysosomes through EGF-triggered endocytosis attenuated zinc-mediated lysosomal membrane permeabilization and neuronal cell death

The Wae to repair: prostaglandin E2 (PGE 2) triggers intestinal wound repair

Methylmalonic acidemia triggers lysosomal-autophagy dysfunctions

mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane permeabilization-mediated autophagy

MLKL polymerization-induced lysosomal membrane permeabilization promotes necroptosis

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

Annexin A7 is required for ESCRT III-mediated plasma membrane repair

Annexin A7 is required for ESCRT III-mediated plasma membrane repair

Mitochondrial translation deficiency impairs NAD + ‐mediated lysosomal acidification

Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization

Mucopolysaccharidosis IIIB, a lysosomal storage disease, triggers a pathogenic CNS autoimmune response

TFEB-mediated lysosomal biogenesis and lysosomal drug sequestration confer resistance to MEK inhibition in pancreatic cancer

An increase of lysosomes through EGF-triggered endocytosis attenuated zinc-mediated lysosomal membrane permeabilization and neuronal cell death

The Wae to repair: prostaglandin E2 (PGE 2) triggers intestinal wound repair

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