Inducin Triggers LC3‐Lipidation and ESCRT‐Mediated Lysosomal Membrane Repair
Abstract: Lipidation of the LC3 protein has frequently been employed as a marker of autophagy. However, LC3‐lipidation is also triggered by stimuli not related to canonical autophagy. Therefore, characterization of the driving parameters for LC3 lipidation is crucial to understanding the biological roles of LC3. We identified a pseudo‐natural product, termed Inducin, that increases LC3 lipidation independently of canonical autophagy, impairs lysosomal function and rapidly recruits Galectin 3 to lysosomes. Inducin treatment promotes Endosomal Sorting Complex Required for Transport (ESCRT)‐dependent membrane repair and transcription factor EB (TFEB)‐dependent lysosome biogenesis ultimately leading to cell death.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Inducin Triggers LC3‐Lipidation and ESCRT‐Mediated Lysosomal Membrane Repair ; day:07 ; month:11 ; year:2023 ; extent:12
ChemBioChem ; (07.11.2023) (gesamt 12)
- Urheber
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Corkery, Dale
Ursu, Andrei
Lucas, Belén
Grigalunas, Michael
Kriegler, Simon
Oliva, Rosario
Dec, Robert
Koska, Sandra
Pahl, Axel
Sievers, Sonja
Ziegler, Slava
Winter, Roland
Wu, Yaowen
Waldmann, Herbert
- DOI
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10.1002/cbic.202300579
- URN
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urn:nbn:de:101:1-2023110814100121448268
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:48 MESZ
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Beteiligte
- Corkery, Dale
- Ursu, Andrei
- Lucas, Belén
- Grigalunas, Michael
- Kriegler, Simon
- Oliva, Rosario
- Dec, Robert
- Koska, Sandra
- Pahl, Axel
- Sievers, Sonja
- Ziegler, Slava
- Winter, Roland
- Wu, Yaowen
- Waldmann, Herbert
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mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane permeabilization-mediated autophagy
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Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice
Annexin A7 is required for ESCRT III-mediated plasma membrane repair
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Mitochondrial translation deficiency impairs NAD + ‐mediated lysosomal acidification
Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization
Mucopolysaccharidosis IIIB, a lysosomal storage disease, triggers a pathogenic CNS autoimmune response
TFEB-mediated lysosomal biogenesis and lysosomal drug sequestration confer resistance to MEK inhibition in pancreatic cancer
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