MicroRNA biogenesis and variability

Abstract: MicroRNAs (miRNAs) are cell-endogenous small noncoding RNAs that, through RNA interference, are involved in the posttranscriptional regulation of mRNAs. The biogenesis and function of miRNAs entail multiple elements with different alternative pathways. These confer a high versatility of regulation and a high variability to generate different miRNAs and hence possess a broad potential to regulate gene expression. Here we review the different mechanisms, both canonical and noncanonical, that generate miRNAs in animals. The ‘miRNome’ panorama enhances our knowledge regarding the fine regulation of gene expression and provides new insights concerning normal, as opposed to pathological, cell differentiation and development.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: MicroRNA biogenesis and variability ; volume:4 ; number:4 ; year:2013 ; pages:367-380 ; Biomolecular concepts ; 4, Heft 4 (2013), 367-380

Contributors, Places and Time

• Creator: García-López, Jesús ; Brieño-Enríquez, Miguel A. ; del Mazo, Jesús

Further information

• DOI: 10.1515/bmc-2013-0015
• URN: urn:nbn:de:101:1-2409241636074.400974504253
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:24 AM CEST