MicroRNA biogenesis and variability
Abstract: MicroRNAs (miRNAs) are cell-endogenous small noncoding RNAs that, through RNA interference, are involved in the posttranscriptional regulation of mRNAs. The biogenesis and function of miRNAs entail multiple elements with different alternative pathways. These confer a high versatility of regulation and a high variability to generate different miRNAs and hence possess a broad potential to regulate gene expression. Here we review the different mechanisms, both canonical and noncanonical, that generate miRNAs in animals. The ‘miRNome’ panorama enhances our knowledge regarding the fine regulation of gene expression and provides new insights concerning normal, as opposed to pathological, cell differentiation and development.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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MicroRNA biogenesis and variability ; volume:4 ; number:4 ; year:2013 ; pages:367-380
Biomolecular concepts ; 4, Heft 4 (2013), 367-380
- Urheber
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García-López, Jesús
Brieño-Enríquez, Miguel A.
del Mazo, Jesús
- DOI
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10.1515/bmc-2013-0015
- URN
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urn:nbn:de:101:1-2409241636074.400974504253
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:24 MESZ
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Beteiligte
- García-López, Jesús
- Brieño-Enríquez, Miguel A.
- del Mazo, Jesús
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