Primary Human Pancreatic Cancer Cells Cultivation in Microfluidic Hydrogel Microcapsules for Drug Evaluation
Abstract: Chemotherapy is an essential postoperative treatment for pancreatic cancer, while due to the lack of effective drug evaluation platforms, the therapeutic outcomes are hampered by tumor heterogeneity among individuals. Here, a novel microfluidic encapsulated and integrated primary pancreatic cancer cells platform is proposed for biomimetic tumor 3D cultivation and clinical drug evaluation. These primary cells are encapsulated into hydrogel microcapsules of carboxymethyl cellulose cores and alginate shells based on a microfluidic electrospray technique. Benefiting from the good monodispersity, stability, and precise dimensional controllability of the technology, the encapsulated cells can proliferate rapidly and spontaneously form 3D tumor spheroids with highly uniform size and good cell viability. By integrating these encapsulated tumor spheroids into a microfluidic chip with concentration gradient channels and culture chambers, dynamic and high‐throughput drug evaluation of different chemotherapy regimens could be realized. It is demonstrated that different patient‐derived tumor spheroids show different drug sensitivity on‐chip, which is significantly consistent with the clinical follow‐up study after the operation. The results demonstrate that the microfluidic encapsulated and integrated tumor spheroids platform has great application potential in clinical drug evaluation.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Primary Human Pancreatic Cancer Cells Cultivation in Microfluidic Hydrogel Microcapsules for Drug Evaluation ; day:19 ; month:02 ; year:2023 ; extent:9
Advanced science ; (19.02.2023) (gesamt 9)
- Urheber
- DOI
-
10.1002/advs.202206004
- URN
-
urn:nbn:de:101:1-2023022014010754002528
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
14.08.2025, 10:57 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Song, Taiyu
- Zhang, Hui
- Luo, Zhiqiang
- Shang, Luoran
- Zhao, Yuanjin
Ähnliche Objekte (12)
Leistungsdiagnostik im Tischtennis : Analyse der realen und der mathematisch-simulativen Spielstärke in der Herren-Weltklasse
Numerical simulation for wormlike chains in two-dimensional confinement
Leistungsdiagnostik im Tischtennis
Developing quantitative assays for six urinary glycoproteins using parallel reaction monitoring, data‐independent acquisition, and TMT‐based data‐dependent acquisition
Invasion ecology of quagga mussels in Lake Constance
The stability with general decay rate of hybrid stochastic fractional differential equations driven by Lévy noise with impulsive effects
A Flexible and Stretchable Triboelectric Nanogenerator with Agarose/P (HEA‐co‐AA)‐Al/NaCl Electrodes for Bio‐Mechanical Energy Harvesting and Fall Detection
Some results on the total proper k -connection number
Black Phosphorus Tagged Responsive Strontium Hydrogel Particles for Bone Defect Repair
Stretchable and Conductive Composite Structural Color Hydrogel Films as Bionic Electronic Skins
Stable and selective permeable hydrogel microcapsules for high-throughput cell cultivation and enzymatic analysis
Is he or she the main player in table tennis mixed doubles?
Leistungsdiagnostik im Tischtennis : Analyse der realen und der mathematisch-simulativen Spielstärke in der Herren-Weltklasse
Numerical simulation for wormlike chains in two-dimensional confinement
Leistungsdiagnostik im Tischtennis
Developing quantitative assays for six urinary glycoproteins using parallel reaction monitoring, data‐independent acquisition, and TMT‐based data‐dependent acquisition
Invasion ecology of quagga mussels in Lake Constance
The stability with general decay rate of hybrid stochastic fractional differential equations driven by Lévy noise with impulsive effects
A Flexible and Stretchable Triboelectric Nanogenerator with Agarose/P (HEA‐co‐AA)‐Al/NaCl Electrodes for Bio‐Mechanical Energy Harvesting and Fall Detection
Some results on the total proper k -connection number
Black Phosphorus Tagged Responsive Strontium Hydrogel Particles for Bone Defect Repair
Stretchable and Conductive Composite Structural Color Hydrogel Films as Bionic Electronic Skins
Stable and selective permeable hydrogel microcapsules for high-throughput cell cultivation and enzymatic analysis
Is he or she the main player in table tennis mixed doubles?
Leistungsdiagnostik im Tischtennis : Analyse der realen und der mathematisch-simulativen Spielstärke in der Herren-Weltklasse
Numerical simulation for wormlike chains in two-dimensional confinement
Leistungsdiagnostik im Tischtennis
Developing quantitative assays for six urinary glycoproteins using parallel reaction monitoring, data‐independent acquisition, and TMT‐based data‐dependent acquisition
Invasion ecology of quagga mussels in Lake Constance
The stability with general decay rate of hybrid stochastic fractional differential equations driven by Lévy noise with impulsive effects
A Flexible and Stretchable Triboelectric Nanogenerator with Agarose/P (HEA‐co‐AA)‐Al/NaCl Electrodes for Bio‐Mechanical Energy Harvesting and Fall Detection
Some results on the total proper k -connection number
Black Phosphorus Tagged Responsive Strontium Hydrogel Particles for Bone Defect Repair
Stretchable and Conductive Composite Structural Color Hydrogel Films as Bionic Electronic Skins
Stable and selective permeable hydrogel microcapsules for high-throughput cell cultivation and enzymatic analysis