Protecting‐Group‐Free Amidation of Amino Acids using Lewis Acid Catalysts
Abstract: Amidation of unprotected amino acids has been investigated using a variety of ‘classical“ coupling reagents, stoichiometric or catalytic group (IV) metal salts, and boron Lewis acids. The scope of the reaction was explored through the attempted synthesis of amides derived from twenty natural, and several unnatural, amino acids, as well as a wide selection of primary and secondary amines. The study also examines the synthesis of medicinally relevant compounds, and the scalability of this direct amidation approach. Finally, we provide insight into the chemoselectivity observed in these reactions.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Protecting‐Group‐Free Amidation of Amino Acids using Lewis Acid Catalysts ; volume:24 ; number:27 ; year:2018 ; pages:7033-7043 ; extent:11
Chemistry - a European journal ; 24, Heft 27 (2018), 7033-7043 (gesamt 11)
- Creator
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Sabatini, Marco T.
Karaluka, Valerija
Lanigan, Rachel M.
Boulton, Lee T.
Badland, Matthew
Sheppard, Tom D.
- DOI
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10.1002/chem.201800372
- URN
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urn:nbn:de:101:1-2022081906525890258687
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:33 AM CEST
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Sabatini, Marco T.
- Karaluka, Valerija
- Lanigan, Rachel M.
- Boulton, Lee T.
- Badland, Matthew
- Sheppard, Tom D.
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