Digital control circuitry for the p53 dynamics in cancer cell and apoptosis
Abstract: Experimental work and theoretical models deduce a “digital” response of the p53 transcription factor when genomic integrity is damaged. The mutual influence of p53 and its antagonist, the Mdm2 oncogene, is closed in a feedback. This paper proposes an aerospace-based architecture for translating the p53/Mdm2/DNA damage network into a digital circuitry in which the optimal control theory is applied for obtaining the requested dynamic evolutions of some considered cell species for repairing a DNA damage. The purpose of this paper is to demonstrate the usefulness of such digital circuitry design to detect and predict the cell species dynamics for shedding light on their inner and mutual mechanisms of interaction. Moreover, the cell fate is newly conceived by the modified pulsing mechanism of p53 and other apoptotic species when the digital optimal control is applied to an apoptosis wiring diagram.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Digital control circuitry for the p53 dynamics in cancer cell and apoptosis ; volume:5 ; number:2 ; year:2010 ; pages:197-213 ; extent:17
Open life sciences ; 5, Heft 2 (2010), 197-213 (gesamt 17)
- Creator
-
Ardito Marretta, Rosario
- DOI
-
10.2478/s11535-009-0068-3
- URN
-
urn:nbn:de:101:1-2409201828133.757836960382
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:29 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Ardito Marretta, Rosario
Other Objects (12)
Aberrant impulse control circuitry in obesity
Severe cellular stress drives apoptosis through a dual control mechanism independently of p53
Functional neuronal circuitry and oscillatory dynamics in human brain organoids
Pinning control for the p53-Mdm2 network dynamics regulated by p14ARF
Imaging the neural circuitry and chemical control of aggressive motivation
Apoptosis and p53 expression in rat adjuvant arthritis
Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53
Engineering optogenetic control of p53
Engineering optogenetic control of p53
Novelty triggers time-dependent theta oscillatory dynamics in cortical-hippocampal-midbrain circuitry
BTK modulates p73 activity to induce apoptosis independently of p53
DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control
Aberrant impulse control circuitry in obesity
Severe cellular stress drives apoptosis through a dual control mechanism independently of p53
Functional neuronal circuitry and oscillatory dynamics in human brain organoids
Pinning control for the p53-Mdm2 network dynamics regulated by p14ARF
Imaging the neural circuitry and chemical control of aggressive motivation
Apoptosis and p53 expression in rat adjuvant arthritis
Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53
Engineering optogenetic control of p53
Engineering optogenetic control of p53
Novelty triggers time-dependent theta oscillatory dynamics in cortical-hippocampal-midbrain circuitry
BTK modulates p73 activity to induce apoptosis independently of p53
DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control
Aberrant impulse control circuitry in obesity
Severe cellular stress drives apoptosis through a dual control mechanism independently of p53
Functional neuronal circuitry and oscillatory dynamics in human brain organoids
Pinning control for the p53-Mdm2 network dynamics regulated by p14ARF
Imaging the neural circuitry and chemical control of aggressive motivation
Apoptosis and p53 expression in rat adjuvant arthritis
Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53
Engineering optogenetic control of p53
Engineering optogenetic control of p53
Novelty triggers time-dependent theta oscillatory dynamics in cortical-hippocampal-midbrain circuitry
BTK modulates p73 activity to induce apoptosis independently of p53