Mitochondrial carriers in inflammation induced by bacterial endotoxin and cytokines
Abstract: Significant metabolic changes occur in the shift from resting to activated cellular status in inflammation. Thus, changes in expression of a large number of genes and extensive metabolic reprogramming gives rise to acquisition of new functions (e.g. production of cytokines, intermediates for biosynthesis, lipid mediators, PGE, ROS and NO). In this context, mitochondrial carriers, which catalyse the transport of solute across mitochondrial membrane, change their expression to transport mitochondrially produced molecules, among which citrate and succinate, to be used as intracellular signalling molecules in inflammation. This review summarises the mitochondrial carriers studied so far that are, directly or indirectly, involved in inflammation.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Mitochondrial carriers in inflammation induced by bacterial endotoxin and cytokines ; volume:398 ; number:3 ; year:2017 ; pages:303-317 ; extent:15
Biological chemistry ; 398, Heft 3 (2017), 303-317 (gesamt 15)
- Urheber
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Iacobazzi, Vito
Infantino, Vittoria
Castegna, Alessandra
Menga, Alessio
Palmieri, Erika Mariana
Convertini, Paolo
Palmieri, Ferdinando
- DOI
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10.1515/hsz-2016-0260
- URN
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urn:nbn:de:101:1-2408061541250.889685211261
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:54 MESZ
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Beteiligte
- Iacobazzi, Vito
- Infantino, Vittoria
- Castegna, Alessandra
- Menga, Alessio
- Palmieri, Erika Mariana
- Convertini, Paolo
- Palmieri, Ferdinando
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