Supramolecular Rotaxane‐Based Multi‐Modal Probes for Cancer Biomarker Imaging **

Abstract: Mechanically interlocked molecules present opportunities to construct therapeutic drugs and diagnostic imaging agents but harnessing supramolecular chemistry to make biologically active probes in water is a challenge. Here, we describe a rotaxane‐based approach to synthesise radiolabelled proteins and peptides for molecular imaging of cancer biomarkers in vivo. Host–guest chemistry using β‐cyclodextrin‐ and cucurbit[6]uril‐catalysed cooperative capture synthesis produced gallium‐68 or zirconium‐89 radiolabelled metallo[4]rotaxanes. Photochemical conjugation to trastuzumab led to a viable positron emission tomography (PET) radiotracer. The rotaxane architecture can be tuned to accommodate different radiometal ion complexes, other protein‐ or peptide‐based drugs, and fluorophores for optical detection. This technology provides a platform to explore how mechanical bonding can improve drug delivery, enhance tumour specificity, control radiotracer pharmacokinetics, and reduce dosimetry.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Supramolecular Rotaxane‐Based Multi‐Modal Probes for Cancer Biomarker Imaging ** ; day:20 ; month:05 ; year:2022 ; extent:1 ; Angewandte Chemie ; (20.05.2022) (gesamt 1)

Beteiligte, Orts- und Zeitangaben

• Urheber: d'Orchymont, Faustine ; Holland, Jason

Weitere Informationen

• DOI: 10.1002/ange.202204072
• URN: urn:nbn:de:101:1-2022052115072713650272
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:33 MESZ