Secretion of full-length Tau or Tau fragments in cell culture models. Propagation of Tau in vivo and in vitro

Abstract: The microtubule-associated protein Tau plays a crucial role in stabilizing neuronal microtubules. In Tauopathies, Tau loses its ability to bind microtubules, detach from them and forms intracellular aggregates. Increasing evidence in recent years supports the notion that Tau pathology spreading throughout the brain in AD and other Tauopathies is the consequence of the propagation of specific Tau species along neuroanatomically connected brain regions in a so-called “prion-like” manner. A number of steps are assumed to be involved in this process, including secretion, cellular uptake, transcellular transfer and/or seeding, although the precise mechanisms underlying propagation of Tau pathology are not fully understood yet. This review summarizes recent evidence on the nature of the specific Tau species that are propagated and the different mechanisms of Tau pathology spreading.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Secretion of full-length Tau or Tau fragments in cell culture models. Propagation of Tau in vivo and in vitro ; volume:9 ; number:1 ; year:2018 ; pages:1-11 ; extent:11 ; Biomolecular concepts ; 9, Heft 1 (2018), 1-11 (gesamt 11)

Contributors, Places and Time

• Creator: Pérez, Mar ; Medina, Miguel ; Hernández, Félix ; Avila, Jesús

Further information

• DOI: 10.1515/bmc-2018-0001
• URN: urn:nbn:de:101:1-2409241644332.332824181730
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:23 AM CEST