Biogenic Imaging Contrast Agents

Abstract: Imaging contrast agents are widely investigated in preclinical and clinical studies, among which biogenic imaging contrast agents (BICAs) are developing rapidly and playing an increasingly important role in biomedical research ranging from subcellular level to individual level. The unique properties of BICAs, including expression by cells as reporters and specific genetic modification, facilitate various in vitro and in vivo studies, such as quantification of gene expression, observation of protein interactions, visualization of cellular proliferation, monitoring of metabolism, and detection of dysfunctions. Furthermore, in human body, BICAs are remarkably helpful for disease diagnosis when the dysregulation of these agents occurs and can be detected through imaging techniques. There are various BICAs matched with a set of imaging techniques, including fluorescent proteins for fluorescence imaging, gas vesicles for ultrasound imaging, and ferritin for magnetic resonance imaging. In addition, bimodal and multimodal imaging can be realized through combining the functions of different BICAs, which helps overcome the limitations of monomodal imaging. In this review, the focus is on the properties, mechanisms, applications, and future directions of BICAs.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Biogenic Imaging Contrast Agents ; day:03 ; month:07 ; year:2023 ; extent:22
Advanced science ; (03.07.2023) (gesamt 22)

Urheber
Dan, Qing
Jiang, Xinpeng
Wang, Run
Dai, Zhifei
Sun, Desheng

DOI
10.1002/advs.202207090
URN
urn:nbn:de:101:1-2023070415102335752893
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
14.08.2025, 10:53 MESZ

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Beteiligte

  • Dan, Qing
  • Jiang, Xinpeng
  • Wang, Run
  • Dai, Zhifei
  • Sun, Desheng

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