Bottom‐Up Assembly of DNA–Silica Nanocomposites into Micrometer‐Sized Hollow Spheres
Abstract: Although DNA nanotechnology has developed into a highly innovative and lively field of research at the interface between chemistry, materials science, and biotechnology, there is still a great need for methodological approaches for bridging the size regime of DNA nanostructures with that of micrometer‐ and millimeter‐sized units for practical applications. We report on novel hierarchically structured composite materials from silica nanoparticles and DNA polymers that can be obtained by self‐assembly through the clamped hybridization chain reaction. The nanocomposite materials can be assembled into thin layers within microfluidically generated water‐in‐oil droplets to produce mechanically stabilized hollow spheres with uniform size distributions at high throughput rates. The fact that cells can be encapsulated in these microcontainers suggests that our concept not only contributes to the further development of supramolecular bottom‐up manufacturing, but can also be exploited for applications in the life sciences.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Bottom‐Up Assembly of DNA–Silica Nanocomposites into Micrometer‐Sized Hollow Spheres ; volume:131 ; number:48 ; year:2019 ; pages:17429-17432 ; extent:4
Angewandte Chemie ; 131, Heft 48 (2019), 17429-17432 (gesamt 4)
- Creator
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Hu, Yong
Grösche, Maximilian
Sheshachala, Sahana
Oelschlaeger, Claude
Willenbacher, Norbert
Rabe, Kersten S.
Niemeyer, Christof M.
- DOI
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10.1002/ange.201910606
- URN
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urn:nbn:de:101:1-2022080908233190747337
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:20 AM CEST
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Associated
- Hu, Yong
- Grösche, Maximilian
- Sheshachala, Sahana
- Oelschlaeger, Claude
- Willenbacher, Norbert
- Rabe, Kersten S.
- Niemeyer, Christof M.
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Bottom‐Up Assembly of DNA–Silica Nanocomposites into Micrometer‐Sized Hollow Spheres
From DNA Nanotechnology to Material Systems Engineering
TRUE ORTHO GENERATION OF URBAN AREA USING HIGH RESOLUTION AERIAL PHOTOS
A novel method to judge the safe position of C2 lamina screw with double holes
Postsynthetic Functionalization of DNA‐Nanocomposites with Proteins Yields Bioinstructive Matrices for Cell Culture Applications
A conformal geometric algebra method for virtual hand modeling and interaction
Magnitude and influencing factors of respiration-induced liver motion during abdominal compression in patients with intrahepatic tumors
Active ankylosing spondylitis increases blood loss during total hip arthroplasty for a stiff hip joint
Electronic landscape of kagome superconductors AV3Sb5 (A = K, Rb, Cs) from angle-resolved photoemission spectroscopy
Depositional environments and petrofacies of X–XII sand groups of K2 qn 3 Formation, Daqingzijing area, Songliao Basin, China
Epidemiological characteristics, diagnosis and treatment effect of rifampicin-resistant pulmonary tuberculosis (RR-PTB) in Guizhou Province
Optimization of Assembly Pipeline may Improve the Sequence of the Chloroplast Genome in Quercus spinosa
Bottom‐Up Assembly of DNA–Silica Nanocomposites into Micrometer‐Sized Hollow Spheres
From DNA Nanotechnology to Material Systems Engineering
TRUE ORTHO GENERATION OF URBAN AREA USING HIGH RESOLUTION AERIAL PHOTOS
A novel method to judge the safe position of C2 lamina screw with double holes
Postsynthetic Functionalization of DNA‐Nanocomposites with Proteins Yields Bioinstructive Matrices for Cell Culture Applications
A conformal geometric algebra method for virtual hand modeling and interaction
Magnitude and influencing factors of respiration-induced liver motion during abdominal compression in patients with intrahepatic tumors
Active ankylosing spondylitis increases blood loss during total hip arthroplasty for a stiff hip joint
Electronic landscape of kagome superconductors AV3Sb5 (A = K, Rb, Cs) from angle-resolved photoemission spectroscopy
Depositional environments and petrofacies of X–XII sand groups of K2 qn 3 Formation, Daqingzijing area, Songliao Basin, China
Epidemiological characteristics, diagnosis and treatment effect of rifampicin-resistant pulmonary tuberculosis (RR-PTB) in Guizhou Province