Chemoselective Acylation of Nucleosides
Abstract: Acylated nucleoside analogues play an important role in medicinal chemistry and are extremely useful precursors to various other nucleoside analogues. However, chemoselective acylation of nucleosides usually requires several protection and deprotection steps due to the competing nucleophilicity of hydroxy and amino groups. In contrast, direct protecting‐group‐free chemoselective acylation of nucleosides is a preferred strategy due to lower cost and fewer overall synthetic steps. Herein, a simple and efficient chemoselective acylation of nucleosides and nucleotides under mild reaction conditions, giving either O‐ or N‐acylated products respectively with excellent chemoselectivity is reported.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Chemoselective Acylation of Nucleosides ; day:26 ; month:07 ; year:2022 ; extent:1
Chemistry - a European journal ; (26.07.2022) (gesamt 1)
- Creator
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Tang, Yu
Grange, Rebecca L.
Engl, Oliver D.
Miller, Scott J.
- DOI
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10.1002/chem.202201661
- URN
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urn:nbn:de:101:1-2022072715015035755317
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:37 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Tang, Yu
- Grange, Rebecca L.
- Engl, Oliver D.
- Miller, Scott J.
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