Peptide and Enzyme Catalysts Work in Concert in Stereoselective Cascade Reactions—Oxidation followed by Conjugate Addition
Abstract: Enzymes and peptide catalysts consist of the same building blocks but require vastly different environments to operate best. Herein, we show that an enzyme and a peptide catalyst can work together in a single reaction vessel to catalyze a two‐step cascade reaction with high chemo‐ and stereoselectivity. Abundant linear alcohols, nitroolefins, an alcohol oxidase, and a tripeptide catalyst provided chiral γ‐nitroaldehydes in aqueous buffer. High yields (up to 92 %) and stereoselectivities (up to 98 % ee) were achieved for the cascade through the rational design of the peptide catalyst and the identification of common reaction conditions.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Peptide and Enzyme Catalysts Work in Concert in Stereoselective Cascade Reactions—Oxidation followed by Conjugate Addition ; day:14 ; month:02 ; year:2024 ; extent:5
Angewandte Chemie ; (14.02.2024) (gesamt 5)
- Creator
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Möhler, Jasper
Pickl, Mathias
Reiter, Tamara
Simić, Stefan
Rackl, Jonas W.
Kroutil, Wolfgang
Wennemers, Helma
- DOI
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10.1002/ange.202319457
- URN
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urn:nbn:de:101:1-2024021514081860298006
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:37 AM CEST
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Associated
- Möhler, Jasper
- Pickl, Mathias
- Reiter, Tamara
- Simić, Stefan
- Rackl, Jonas W.
- Kroutil, Wolfgang
- Wennemers, Helma
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