Connecting Algal Polysaccharide Degradation to Formaldehyde Detoxification

Abstract: Formaldehyde is a toxic metabolite that is formed in large quantities during bacterial utilization of the methoxy sugar 6‐O‐methyl‐d‐galactose, an abundant monosaccharide in the red algal polysaccharide porphyran. Marine bacteria capable of metabolizing porphyran must therefore possess suitable detoxification systems for formaldehyde. We demonstrate here that detoxification of formaldehyde in the marine Flavobacterium Zobellia galactanivorans proceeds via the ribulose monophosphate pathway. Simultaneously, we show that the genes encoding the key enzymes of this pathway are important for maintaining high formaldehyde resistance. Additionally, these genes are upregulated in the presence of porphyran, allowing us to connect porphyran degradation to the detoxification of formed formaldehyde.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Connecting Algal Polysaccharide Degradation to Formaldehyde Detoxification ; day:30 ; month:05 ; year:2022 ; extent:1 ; ChemBioChem ; (30.05.2022) (gesamt 1)

Contributors, Places and Time

• Creator: Brott, Stefan ; Thomas, François ; Behrens, Maike ; Methling, Karen ; Bartosik, Daniel ; Dutschei, Theresa ; Lalk, Michael ; Michel, Gurvan ; Schweder, Thomas ; Bornscheuer, Uwe Theo

Further information

• DOI: 10.1002/cbic.202200269
• URN: urn:nbn:de:101:1-2022053115021994938613
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:22 AM CEST