The Chemistry of Angucyclines

Abstract: Angucyclines and angucyclinones represent a class of natural compounds that belong to the group of aromatic polyketides. They exhibit a wide array of biological properties, such as antimicrobial, antiviral, and cytotoxic. Their considerable therapeutic potential and diverse scaffolds have attracted many synthetic chemists to devise novel strategies to construct their intricate molecular architecture. Over 300 class members have been isolated from natural sources, mainly from bacterial strains of Streptomyces species. This review highlights recent advancements in their synthesis, such as oxidative cyclization, photooxidation, and metal‐catalyzed [4+2]‐cycloaddition, which has facilitated the efficient and practical total syntheses of various angucycline and angucyclinone natural products.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: The Chemistry of Angucyclines ; day:21 ; month:08 ; year:2024 ; extent:15 ; ChemPlusChem ; (21.08.2024) (gesamt 15)

Contributors, Places and Time

• Creator: Vysloužilová, Denisa ; Kováč, Ondřej

Further information

• DOI: 10.1002/cplu.202400307
• URN: urn:nbn:de:101:1-2408221413290.942390831104
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 11:02 AM CEST