Dyslipidemia in retinal metabolic disorders
Abstract: The light‐sensitive photoreceptors in the retina are extremely metabolically demanding and have the highest density of mitochondria of any cell in the body. Both physiological and pathological retinal vascular growth and regression are controlled by photoreceptor energy demands. It is critical to understand the energy demands of photoreceptors and fuel sources supplying them to understand neurovascular diseases. Retinas are very rich in lipids, which are continuously recycled as lipid‐rich photoreceptor outer segments are shed and reformed and dietary intake of lipids modulates retinal lipid composition. Lipids (as well as glucose) are fuel substrates for photoreceptor mitochondria. Dyslipidemia contributes to the development and progression of retinal dysfunction in many eye diseases. Here, we review photoreceptor energy demands with a focus on lipid metabolism in retinal neurovascular disorders.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Dyslipidemia in retinal metabolic disorders ; volume:11 ; number:10 ; year:2019 ; extent:15
EMBO molecular medicine / European Molecular Biology Organization ; 11, Heft 10 (2019) (gesamt 15)
- Urheber
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Fu, Zhongjie
Chen, Chuck T.
Cagnone, Gael
Heckel, Emilie
Sun, Ye
Cakir, Bertan
Tomita, Yohei
Huang, Shuo
Li, Qian
Britton, William
Cho, Steve S.
Kern, Timothy S.
Hellström, Ann
Joyal, Jean‐Sébastien
Smith, Lois EH
- DOI
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10.15252/emmm.201910473
- URN
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urn:nbn:de:101:1-2022072008494346756716
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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08.08.2025, 01:34 MESZ
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Beteiligte
- Fu, Zhongjie
- Chen, Chuck T.
- Cagnone, Gael
- Heckel, Emilie
- Sun, Ye
- Cakir, Bertan
- Tomita, Yohei
- Huang, Shuo
- Li, Qian
- Britton, William
- Cho, Steve S.
- Kern, Timothy S.
- Hellström, Ann
- Joyal, Jean‐Sébastien
- Smith, Lois EH
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