FAM69C functions as a kinase for eIF2α and promotes stress granule assembly
Abstract: Stress granules are dynamic cytoplasmic ribonucleoprotein granules that assemble in response to cellular stress. Aberrant formation of stress granules has been linked to neurodegenerative diseases. However, the molecular mechanisms underlying the initiation of stress granules remain elusive. Here we report that the brain‐enriched protein kinase FAM69C promotes stress granule assembly through phosphorylation of eukaryotic translation initiation factor 2 (eIF2α). FAM69C physically interacts with eIF2α and functions as a stress‐specific kinase for eIF2α, leading to stress‐induced protein translation arrest and stress granule assembly. Primary microglia derived from Fam69c knockout mice exhibit aberrant stress granule assembly in response to oxidative stress and ATP. Defective stress granule assembly in microglia correlates with the formation of ASC specks and NLRP3 inflammasome activation, whereas induction of stress granule precludes inflammasome formation. Consistently, increased NLRP3 levels, caspase‐1 cleavage and Il18 expression corroborate microglia‐associated neuroinflammation in aged Fam69c knockout mice. Our study demonstrates that FAM69C is critical for stress granule assembly and suggests its role in the regulation of microglia function.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
FAM69C functions as a kinase for eIF2α and promotes stress granule assembly ; day:16 ; month:03 ; year:2023 ; extent:15
EMBO reports / European Molecular Biology Organization ; (16.03.2023) (gesamt 15)
- Creator
-
Wu, Zhongyan
Mei, Fan
Gan, Yangyang
Liu, Anhang
Hu, Jiapan
Jin, Yan
Yin, Yuxin
- DOI
-
10.15252/embr.202255641
- URN
-
urn:nbn:de:101:1-2023031714022677216198
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
14.08.2025, 10:49 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Wu, Zhongyan
- Mei, Fan
- Gan, Yangyang
- Liu, Anhang
- Hu, Jiapan
- Jin, Yan
- Yin, Yuxin
Other Objects (12)
Construct and content in context: implications for language learning, teaching and assessment in China
Consequential research of accountability testing: the case of the CET
Current progress of skin tissue engineering: Seed cells, bioscaffolds, and construction strategies
Changes of East Asian summer monsoon due to tropical air-sea interactions induced by a global warming scenario
Have inequalities in all-cause and cause-specific child mortality between countries declined across the world?
The mTOR-S6 kinase pathway promotes stress granule assembly
Gold nanorod-based FRET assay for selection of G-quadruplex-binding ligands
A quasi-monolithic phase-field description for mixed-mode fracture using predictor–corrector mesh adaptivity
Outpatient scheduling problem in smart hospital with two-agent deep reinforcement learning algorithm
Membrane protein trafficking in the anti-tumor immune response: work of endosomal-lysosomal system
Surgical repair for left coronary artery-right atrium fistula with giant coronary aneurysm
A quasi-monolithic phase-field description for mixed-mode fracture using predictor–corrector mesh adaptivity
Construct and content in context: implications for language learning, teaching and assessment in China
Consequential research of accountability testing: the case of the CET
Current progress of skin tissue engineering: Seed cells, bioscaffolds, and construction strategies
Changes of East Asian summer monsoon due to tropical air-sea interactions induced by a global warming scenario
Have inequalities in all-cause and cause-specific child mortality between countries declined across the world?
The mTOR-S6 kinase pathway promotes stress granule assembly
Gold nanorod-based FRET assay for selection of G-quadruplex-binding ligands
A quasi-monolithic phase-field description for mixed-mode fracture using predictor–corrector mesh adaptivity
Outpatient scheduling problem in smart hospital with two-agent deep reinforcement learning algorithm
Membrane protein trafficking in the anti-tumor immune response: work of endosomal-lysosomal system
Surgical repair for left coronary artery-right atrium fistula with giant coronary aneurysm
A quasi-monolithic phase-field description for mixed-mode fracture using predictor–corrector mesh adaptivity
Construct and content in context: implications for language learning, teaching and assessment in China
Consequential research of accountability testing: the case of the CET
Current progress of skin tissue engineering: Seed cells, bioscaffolds, and construction strategies
Changes of East Asian summer monsoon due to tropical air-sea interactions induced by a global warming scenario
Have inequalities in all-cause and cause-specific child mortality between countries declined across the world?
The mTOR-S6 kinase pathway promotes stress granule assembly
Gold nanorod-based FRET assay for selection of G-quadruplex-binding ligands
A quasi-monolithic phase-field description for mixed-mode fracture using predictor–corrector mesh adaptivity
Outpatient scheduling problem in smart hospital with two-agent deep reinforcement learning algorithm
Membrane protein trafficking in the anti-tumor immune response: work of endosomal-lysosomal system
Surgical repair for left coronary artery-right atrium fistula with giant coronary aneurysm