Pancreatic Adenocarcinoma with Co-Occurrence of KRAS and EGFR Mutations: Case Report and Literature Review

zu Verbundenen Objekten

Abstract: Introduction: Mutation in Kristin ras sarcoma virus (KRAS) oncogene is the main driver in pancreatic ductal adenocarcinoma (PDAC) and is present in nearly 90% of patients with PDAC. Epidermal growth factor receptor (EGFR) mutation is rare in PDAC and is mostly present in the absence of KRAS mutation. Co-occurrence of KRAS and EGFR mutations is extremely rare, and the value of EGFR inhibition in these cases is unknown. Case Presentation: Here, we present a case of metastatic PDAC with co-occurrence of KRAS G12V and EGFR L730R. Despite primary resistance to folinic acid, fluorouracil, irinotecan, oxaliplatin, and gemcitabine/nab-paclitaxel, this patient had a biochemical response (decrease in carbohydrate antigen 19-9) and disease control of 7 months on gemcitabine/erlotinib (an EGFR inhibitor). This outcome is remarkable in the late-line PDAC treatment setting and is unusual after the progression of the tumor on gemcitabine/nab-paclitaxel chemotherapy. Conclusion: This case suggests that gemcitabine/erlotinib could be an effective treatment in patients with PDAC and co-occurrence of EGFR and KRAS mutations.

Standort: Deutsche Nationalbibliothek Frankfurt am Main

Umfang: Online-Ressource

Sprache: Englisch

Erschienen in: Pancreatic Adenocarcinoma with Co-Occurrence of KRAS and EGFR Mutations: Case Report and Literature Review ; volume:17 ; number:1 ; year:2024 ; pages:399-406 ; extent:8
Case reports in oncology ; 17, Heft 1 (2024), 399-406 (gesamt 8)

Urheber: Mody, Juhi
Kamgar, Mandana

DOI: 10.1159/000536552

URN: urn:nbn:de:101:1-2406270104527.377232406244

Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Letzte Aktualisierung: 14.08.2025, 10:53 MESZ

Datenpartner

Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.

Original beim Datenpartner anzeigen

Beteiligte

Mody, Juhi
Kamgar, Mandana

Ähnliche Objekte (12)

Co-Occurrence Conundrum: Brain Metastases from Lung Adenocarcinoma, Radiation Necrosis, and Gliosarcoma

Co-occurrence based texture synthesis

Structure analysis of co-occurrence data

Maximal Mixed-Drove Co-occurrence Patterns

Evolutionary cores of domain co-occurrence networks

Hochschulschrift

Co-occurrence of transcription factor binding sites

Identification of somatic mutations in EGFR/KRAS/ALK-negative lung adenocarcinoma in never-smokers

p65BTK is a novel potential actionable target in KRAS-mutated/EGFR-wild type lung adenocarcinoma

Cooperatively Managing and Exploiting Distributed Co-occurrence Graphs

Co-occurrence of anaerobic bacteria in colorectal carcinomas

Cooperatively Managing and Exploiting Distributed Co-occurrence Graphs

Constructing gene similarity networks using co-occurrence probabilities

Co-Occurrence Conundrum: Brain Metastases from Lung Adenocarcinoma, Radiation Necrosis, and Gliosarcoma

Co-occurrence based texture synthesis

Structure analysis of co-occurrence data

Maximal Mixed-Drove Co-occurrence Patterns

Evolutionary cores of domain co-occurrence networks

Hochschulschrift

Co-occurrence of transcription factor binding sites

Identification of somatic mutations in EGFR/KRAS/ALK-negative lung adenocarcinoma in never-smokers

p65BTK is a novel potential actionable target in KRAS-mutated/EGFR-wild type lung adenocarcinoma

Cooperatively Managing and Exploiting Distributed Co-occurrence Graphs

Co-occurrence of anaerobic bacteria in colorectal carcinomas

Cooperatively Managing and Exploiting Distributed Co-occurrence Graphs

Constructing gene similarity networks using co-occurrence probabilities

Co-Occurrence Conundrum: Brain Metastases from Lung Adenocarcinoma, Radiation Necrosis, and Gliosarcoma

Co-occurrence based texture synthesis

Structure analysis of co-occurrence data

Maximal Mixed-Drove Co-occurrence Patterns

Evolutionary cores of domain co-occurrence networks

Hochschulschrift

Co-occurrence of transcription factor binding sites

Identification of somatic mutations in EGFR/KRAS/ALK-negative lung adenocarcinoma in never-smokers

p65BTK is a novel potential actionable target in KRAS-mutated/EGFR-wild type lung adenocarcinoma

Cooperatively Managing and Exploiting Distributed Co-occurrence Graphs

Co-occurrence of anaerobic bacteria in colorectal carcinomas

Cooperatively Managing and Exploiting Distributed Co-occurrence Graphs

Constructing gene similarity networks using co-occurrence probabilities

Informationen zur Registrierung von Kultur- und Wissenseinrichtungen finden Sie hier.

Felder mit * müssen ausgefüllt werden.

Benutzername*

Bitte geben Sie Ihren Benutzernamen ein

E-Mail*

Bitte geben Sie Ihre E-Mail ein

Bitte füllen Sie dieses Feld nicht aus

Vorname

Nachname

Passwort*

Bitte geben Sie Ihr Passwort ein

Passwort bestätigen*

Bitte geben Sie das gleiche Passwort ein

Ich habe die Nutzungsbedingungen und die Datenschutzerklärung zur Erhebung persönlicher Daten gelesen und stimme ihnen zu. *

Dieses Feld ist ein Pflichtfeld.

Ich möchte den Newsletter der Deutschen Digitalen Bibliothek abonnieren. Siehe Informationen zum Newsletter-Abonnement.

Benutzerkonto angelegt

Ihr „Meine DDB“-Konto wurde erfolgreich angelegt. Bevor Sie sich in Ihrem Konto anmelden können, müssen Sie auf den Bestätigungslink in der Nachricht klicken, die wir gerade an die von Ihnen angegebene E-Mail-Adresse geschickt haben

Pancreatic Adenocarcinoma with Co-Occurrence of KRAS and EGFR Mutations: Case Report and Literature Review

Angaben zum Objekt

Verweise und Beziehungen

Beteiligte, Orts- und Zeitangaben

Weitere Informationen

Datenpartner

Beteiligte

Ähnliche Objekte (12)

Co-Occurrence Conundrum: Brain Metastases from Lung Adenocarcinoma, Radiation Necrosis, and Gliosarcoma

Co-occurrence based texture synthesis

Structure analysis of co-occurrence data

Maximal Mixed-Drove Co-occurrence Patterns

Evolutionary cores of domain co-occurrence networks

Co-occurrence of transcription factor binding sites

Identification of somatic mutations in EGFR/KRAS/ALK-negative lung adenocarcinoma in never-smokers

p65BTK is a novel potential actionable target in KRAS-mutated/EGFR-wild type lung adenocarcinoma

Cooperatively Managing and Exploiting Distributed Co-occurrence Graphs

Co-occurrence of anaerobic bacteria in colorectal carcinomas

Cooperatively Managing and Exploiting Distributed Co-occurrence Graphs

Constructing gene similarity networks using co-occurrence probabilities

Co-Occurrence Conundrum: Brain Metastases from Lung Adenocarcinoma, Radiation Necrosis, and Gliosarcoma

Co-occurrence based texture synthesis

Structure analysis of co-occurrence data

Maximal Mixed-Drove Co-occurrence Patterns

Evolutionary cores of domain co-occurrence networks

Co-occurrence of transcription factor binding sites

Identification of somatic mutations in EGFR/KRAS/ALK-negative lung adenocarcinoma in never-smokers

p65BTK is a novel potential actionable target in KRAS-mutated/EGFR-wild type lung adenocarcinoma

Cooperatively Managing and Exploiting Distributed Co-occurrence Graphs

Co-occurrence of anaerobic bacteria in colorectal carcinomas

Cooperatively Managing and Exploiting Distributed Co-occurrence Graphs

Constructing gene similarity networks using co-occurrence probabilities

Co-Occurrence Conundrum: Brain Metastases from Lung Adenocarcinoma, Radiation Necrosis, and Gliosarcoma

Co-occurrence based texture synthesis

Structure analysis of co-occurrence data

Maximal Mixed-Drove Co-occurrence Patterns

Evolutionary cores of domain co-occurrence networks

Co-occurrence of transcription factor binding sites

Identification of somatic mutations in EGFR/KRAS/ALK-negative lung adenocarcinoma in never-smokers

p65BTK is a novel potential actionable target in KRAS-mutated/EGFR-wild type lung adenocarcinoma

Cooperatively Managing and Exploiting Distributed Co-occurrence Graphs

Co-occurrence of anaerobic bacteria in colorectal carcinomas

Cooperatively Managing and Exploiting Distributed Co-occurrence Graphs

Constructing gene similarity networks using co-occurrence probabilities

Verbundene Objekte

Passwort zurücksetzen