Mass‐Spectrometric Identification of Proteins and Pathways Responsible for Fouling on Poly (ethylene glycol) Methacrylate Polymer Brushes
Abstract: Prevention of fouling from proteins in blood plasma attracts significant efforts, and great progress is made in identifying surface coatings that display antifouling properties. In particular, poly (ethylene glycol) (PEG) is widely used and dense PEG‐like cylindrical brushes of poly[oligo (ethylene glycol) methacrylate] (poly (OEGMA)) can drastically reduce blood plasma fouling. Herein, a comprehensive study of the variation of blood plasma fouling on this surface, including the analysis of the composition of protein deposits on poly (OEGMA) coatings after contact with blood plasma from many different donors, is reported. Correlation between the plasma fouling behavior and protein deposit composition points to the activation of the complement system as the main culprit of dramatically increased and accelerated deposition of blood plasma proteins on this type of antifouling coating, specifically through the classical pathway. These findings are consistent with observations on PEGylated drug carriers and highlight the importance of understanding the potential interactions between antifouling coatings and their environment.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Mass‐Spectrometric Identification of Proteins and Pathways Responsible for Fouling on Poly (ethylene glycol) Methacrylate Polymer Brushes ; day:26 ; month:02 ; year:2024 ; extent:11
Macromolecular bioscience ; (26.02.2024) (gesamt 11)
- Creator
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Riedelová, Zuzana
de los Santos Pereira, Andres
Dorado Daza, Diego Fernando
Májek, Pavel
Dyčka, Filip
Riedel, Tomáš
- DOI
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10.1002/mabi.202300558
- URN
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urn:nbn:de:101:1-2024022714035247846752
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:52 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Riedelová, Zuzana
- de los Santos Pereira, Andres
- Dorado Daza, Diego Fernando
- Májek, Pavel
- Dyčka, Filip
- Riedel, Tomáš
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Marine Fouling Release Performance of Amphiphilic Carboxybetaine Perfluoropolyether Methacrylate Polymer Coatings
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Handbook heat exchanger fouling : mitigation and cleaning technologies = Wärmetauscher fouling
Investigation of the thermal properties of glycidyl methacrylate–ethylene glycol dimethacrylate copolymeric microspheres modified by Diels–Alder reaction
Grafting of functional methacrylate polymer brushes by photoinduced SET-LRP
Sulfobetaine methacrylate hydrogel-coated anti-fouling surfaces for implantable biomedical devices
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