Ferroptosis Inducing Co (III) Polypyridine Sulfasalazine Complex for Therapeutically Enhanced Anticancer Therapy
Abstract: Despite significant improvements in the treatment of cancerous tumors in the last decades, cancer remains one of the deadliest diseases worldwide. To overcome the shortcomings of currently applied chemotherapeutic treatments, much research efforts have been devoted towards the development of ferroptosis inducing anticancer agents. Ferroptosis is a newly described form of regulated, non‐apoptotic cell death that is associated with high potential inside the clinics. Herein, the chemical synthesis and biological evaluation of a Co (III) polypyridine sulfasalazine complex as a ferroptosis inducer is reported. Upon entering the cancerous cells, the metal complex primarily accumulated in the mitochondria, triggering the production of hydroxy radicals and lipid peroxides, ultimately causing cell death by ferroptosis. The compound demonstrated to eradicate various monolayer cancer cells as well as colon carcinoma multicellular tumor spheroids. To the best of our knowledge this study reports on the first example of a Co (III) complex that is capable of inducing ferroptosis.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Ferroptosis Inducing Co (III) Polypyridine Sulfasalazine Complex for Therapeutically Enhanced Anticancer Therapy ; day:30 ; month:10 ; year:2024 ; extent:10
Angewandte Chemie / International edition. International edition ; (30.10.2024) (gesamt 10)
- Creator
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Montesdeoca, Nicolás
Johannknecht, Lukas
Efanova, Elizaveta
Heinen‐Weiler, Jacqueline
Karges, Johannes
- DOI
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10.1002/anie.202412585
- URN
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urn:nbn:de:101:1-2410301404116.842199518992
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:36 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Montesdeoca, Nicolás
- Johannknecht, Lukas
- Efanova, Elizaveta
- Heinen‐Weiler, Jacqueline
- Karges, Johannes
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Capsaicin Enhanced the Efficacy of Photodynamic Therapy Against Osteosarcoma via a Pro‐Death Strategy by Inducing Ferroptosis and Alleviating Hypoxia
Kayadiol exerted anticancer effects through p53-mediated ferroptosis in NKTCL cells
Dietary iodine attenuates allergic rhinitis by inducing ferroptosis in activated B cells
Creatine Promotes Endometriosis by Inducing Ferroptosis Resistance via Suppression of PrP
Sterigmatocystin declines mouse oocyte quality by inducing ferroptosis and asymmetric division defects
Photo‐Enhanced Synergistic Induction of Ferroptosis for Anti‐Cancer Immunotherapy
Piezoelectric enhanced sulfur doped graphdiyne nanozymes for synergistic ferroptosis–apoptosis anticancer therapy
Ferroptosis, necroptosis, and pyroptosis in anticancer immunity
Rhodium complex [RhLI2]I: a novel anticancer agent inducing tumor inhibition and apoptosis
Ferroptosis-inducing agents compromise in vitro human islet viability and function
ApInAPDB: a database of apoptosis-inducing anticancer peptides
Anticancer Aminoferrocene Derivatives Inducing Production of Mitochondrial Reactive Oxygen Species
Capsaicin Enhanced the Efficacy of Photodynamic Therapy Against Osteosarcoma via a Pro‐Death Strategy by Inducing Ferroptosis and Alleviating Hypoxia
Kayadiol exerted anticancer effects through p53-mediated ferroptosis in NKTCL cells
Dietary iodine attenuates allergic rhinitis by inducing ferroptosis in activated B cells
Creatine Promotes Endometriosis by Inducing Ferroptosis Resistance via Suppression of PrP