C‐type lectin receptors of the Dectin‐1 cluster: Physiological roles and involvement in disease

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Abstract: C‐type lectin receptors (CLRs) are essential for multicellular existence, having diverse functions ranging from embryonic development to immune function. One subgroup of CLRs is the Dectin‐1 cluster, comprising of seven receptors including MICL, CLEC‐2, CLEC‐12B, CLEC‐9A, MelLec, Dectin‐1, and LOX‐1. Reflecting the larger CLR family, the Dectin‐1 cluster of receptors has a broad range of ligands and functions, but importantly, is involved in numerous pathophysiological processes that regulate health and disease. Indeed, these receptors have been implicated in development, infection, regulation of inflammation, allergy, transplantation tolerance, cancer, cardiovascular disease, arthritis, and other autoimmune diseases. In this mini‐review, we discuss the latest advancements in elucidating the function (s) of each of the Dectin‐1 cluster CLRs, focussing on their physiological roles and involvement in disease.

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
C‐type lectin receptors of the Dectin‐1 cluster: Physiological roles and involvement in disease ; volume:49 ; number:12 ; year:2019 ; pages:2127-2133 ; extent:7
European journal of immunology ; 49, Heft 12 (2019), 2127-2133 (gesamt 7)

Creator
Tone, Kazuya
Stappers, Mark H.T.
Willment, Janet A.
Brown, Gordon D.

DOI
10.1002/eji.201847536
URN
urn:nbn:de:101:1-2022072415241999131463
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
15.08.2025, 7:37 AM CEST

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Associated

  • Tone, Kazuya
  • Stappers, Mark H.T.
  • Willment, Janet A.
  • Brown, Gordon D.

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