CYP2C19 genotype-phenotype correlation: current insights and unanswered questions

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Abstract: The CYP2C19 enzyme is implicated in the metabolism of several clinically used drugs. Its phenotype is usually predicted by genotyping and indicates the expected enzymatic activity for each patient. However, with a few exceptions, CYP2C19 genotyping has not resulted in a reliable prediction of the metabolizer status, since most of the evidence currently available for this prediction comes from research into populations of predominantly European ancestry. Therefore, this review discusses the main factors that may alter the expected phenotype, as well as the urgent need to include ethnically diverse populations in further studies, so that, in the long term, it is possible to establish guidelines appropriate to these groups.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
CYP2C19 genotype-phenotype correlation: current insights and unanswered questions ; volume:39 ; number:4 ; year:2024 ; pages:201-206 ; extent:06
Drug metabolism and personalized therapy ; 39, Heft 4 (2024), 201-206 (gesamt 06)

Urheber
Torso, Nadine de Godoy
Rodrigues-Soares, Fernanda
Altamirano, Catalina
Ramírez-Roa, Ronald
Sosa-Macías, Martha
Galavíz-Hernández, Carlos
Terán, Enrique
Peñas-LLedó, Eva
Dorado, Pedro
LLerena, Adrián

DOI
10.1515/dmpt-2024-0093
URN
urn:nbn:de:101:1-2501161313438.259472344023
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:25 MESZ

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Beteiligte

  • Torso, Nadine de Godoy
  • Rodrigues-Soares, Fernanda
  • Altamirano, Catalina
  • Ramírez-Roa, Ronald
  • Sosa-Macías, Martha
  • Galavíz-Hernández, Carlos
  • Terán, Enrique
  • Peñas-LLedó, Eva
  • Dorado, Pedro
  • LLerena, Adrián

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