Differential Oral Microbial Input Determines Two Microbiota Pneumo‐Types Associated with Health Status
Abstract: The oral and upper respiratory tracts are closely linked anatomically and physiologically with the lower respiratory tract and lungs, and the influence of oral and upper respiratory microbes on the lung microbiota is increasingly being recognized. However, the ecological process and individual heterogeneity of the oral and upper respiratory tract microbes shaping the lung microbiota remain unclear owing to the lack of controlled analyses with sufficient sample sizes. Here, the microbiomes of saliva, nasal cavity, oropharyngeal area, and bronchoalveolar lavage samples are profiled and the shaping process of multisource microbes on the lung microbiota is measured. It is found that oral and nasal microbial inputs jointly shape the lung microbiota by occupying different ecological niches. It is also observed that the spread of oral microbes to the lungs is heterogeneous, with more oral microbes entering the lungs being associated with decreased lung function and increased lung proinflammatory cytokines. These results depict the external shaping process of lung microbiota and indicate the great value of oral samples, such as saliva, in monitoring and assessing lung microbiota status in clinical settings.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Differential Oral Microbial Input Determines Two Microbiota Pneumo‐Types Associated with Health Status ; day:28 ; month:08 ; year:2022 ; extent:15
Advanced science ; (28.08.2022) (gesamt 15)
- Creator
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Zhang, Jingxiang
Wu, Yiping
Liu, Jing
Yang, Yongqiang
Li, Hui
Wu, Xiaorong
Zheng, Xiaobin
Liang, Yingjian
Tu, Changli
Chen, Meizhu
Tan, Cuiyan
Chang, Bozhen
Huang, Yiying
Wang, Zhengguo
Tian, Guo‐Bao
Ding, Tao
- DOI
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10.1002/advs.202203115
- URN
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urn:nbn:de:101:1-2022083015290983384277
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:22 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Zhang, Jingxiang
- Wu, Yiping
- Liu, Jing
- Yang, Yongqiang
- Li, Hui
- Wu, Xiaorong
- Zheng, Xiaobin
- Liang, Yingjian
- Tu, Changli
- Chen, Meizhu
- Tan, Cuiyan
- Chang, Bozhen
- Huang, Yiying
- Wang, Zhengguo
- Tian, Guo‐Bao
- Ding, Tao
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