First Interobserver Agreement of Optical Coherence Tomography in the Bile Duct: A Multicenter Collaborative Study

Introduction: Optical coherence tomography (OCT) is a new technology available for evaluation of indeterminate biliary strictures. It allows under-the-surface visualization and preliminary studies have confirmed standardized characteristics associated with malignancy. The aim of this study is to evaluate the first inter-observer agreement in identifying previously agreed upon OCT criteria and diagnosing of malignant versus benign disease. Methods: Fourteen endoscopists were asked to review an atlas of reference clips and images of 8 criteria derived from expert consensus A total of 35 de-identified video clips were then evaluated for presence of the 8 criteria and for final diagnosis of malignant versus benign using the atlas as reference Intraclass correlation (ICC) analysis was done to evaluate interrater agreement. Results: Clips of 23 malignant lesions and 12 benign lesions were scored. Excellent interobserver agreement was seen with dilated hypo-reflective structures (0.85) and layering effacement (0.89); hyper-glandular mucosa (0.76), intact layering (0.81), and onion-skin layering (0.77); fair agreement was seen with scalloping (0.58), and thickened epithelium (0.4); poor agreement was seen with hyper-reflective surface (0.36). The diagnostic ICC for both neoplastic (0.8) and non-neoplastic (0.8) was excellent interobserver agreement. The overall diagnostic accuracy was 51%, ranging from 43% to 60%. Conclusion: Biliary OCT is a promising new modality for evaluation of indeterminate biliary strictures. Inter-observer agreement ranged from fair to almost perfect on 8 previously identified criteria. Interobserver agreement for malignancy diagnosis was substantial (0.8). Further studies are needed to validate this data.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: First Interobserver Agreement of Optical Coherence Tomography in the Bile Duct: A Multicenter Collaborative Study ; day:22 ; month:03 ; year:2022 ; Endoscopy International Open ; (22.03.2022)

Contributors, Places and Time

• Contributor: Tyberg, Amy ; Raijman, I. ; Gaidhane, Monica R. ; Shahid, Haroon ; Sarkar, Avik ; Samarasena, Jason ; Andalib, Iman ; Diehl, David L. ; Pleskow, Douglas ; Woods, Kevin ; Gordon, Stuart R. ; Pannala, Rahul ; Kedia, Prashant ; Draganov, Peter V. ; Tarnasky, Paul ; Sejpal, Divyesh V. ; Kumta, Nikhil A. ; Parasher, Gulshan ; Adler, Douglas G. ; Patel, Kalpesh K. ; Yang, Dennis ; Siddiqui, Uzma D. ; Kahaleh, Michel ; Joshi, Virendra

Further information

• DOI: 10.1055/a-1779-5027
• URN: urn:nbn:de:101:1-2022050512441782309526
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:19 AM CEST