Proinflammatory Cytokine Profile Differences between Primary Open-Angle and Pseudoexfoliative Glaucoma
Introduction: Few studies have investigated glaucoma biomarkers in aqueous humor and tear and have found elevations of proinflammatory cytokines in patients with primary open-angle glaucoma (POAG) and pseudoexfoliative glaucoma (PXG). In this study, we investigate differences in inflammatory cytokines between POAG and PXG patients to find specific disease biomarkers. Methods: For this purpose, tear and aqueous humor samples of 14 eyes with POAG and 15 eyes with PXG undergoing cataract surgery were immunoassayed for 27 proinflammatory cytokines. The concentrations of cytokines in tear and aqueous humor and their association with clinical variables were analyzed, correlated, and compared between the groups. Results: We found that the levels of three cytokines differed significantly in the aqueous humor of POAG and PXG patients: IL-12 and IL-13 were higher in the POAG group, while monocyte chemoattractant protein-1 (monocyte chemotactic and activating factor) was higher in the PXG group. The number of topical hypotensive medications was correlated with diminished levels of two cytokines (IL-7 and basic fibroblast growth factor) in aqueous humor in the POAG group and with diminished levels of IL-12 in tear in the PXG group. Conclusion: We conclude that both POAG and PXG show elevated concentrations of proinflammatory cytokines in tear and aqueous humor that could be used as biomarkers for these types of glaucoma and that the concentrations in aqueous humor of three cytokines, IL-12, IL-13, and monocyte chemoattractant protein-1 (monocyte chemotactic and activating factor), could be used to differentiate POAG and PXG.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Proinflammatory Cytokine Profile Differences between Primary Open-Angle and Pseudoexfoliative Glaucoma ; volume:65 ; number:1 ; year:2021 ; pages:111-120 ; extent:10
Ophthalmic research ; 65, Heft 1 (2021), 111-120 (gesamt 10)
- Creator
-
Vidal-Villegas, Beatriz
Burgos-Blasco, Bárbara
Santiago Alvarez, Jose Luis
Espino-Paisán, Laura
Fernández-Vigo, Jose
Andrés-Guerrero, Vanessa
García-Feijoo, Julián
Martínez-de-la-Casa, Jose María
- DOI
-
10.1159/000519816
- URN
-
urn:nbn:de:101:1-2022020923220352096198
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:37 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Vidal-Villegas, Beatriz
- Burgos-Blasco, Bárbara
- Santiago Alvarez, Jose Luis
- Espino-Paisán, Laura
- Fernández-Vigo, Jose
- Andrés-Guerrero, Vanessa
- García-Feijoo, Julián
- Martínez-de-la-Casa, Jose María
Other Objects (12)
Amlodipine increases risk of primary open-angle glaucoma
Differences in optic nerve head structure between acute angle-closure glaucoma and open-angle glaucoma
Repeatability of selective laser trabeculoplasty for open-angle glaucoma
Genetic association of ANGPT2 with primary open-angle glaucoma
Uneventful Phacoemulsification after Trabeculectomy in Pseudoexfoliation Glaucoma versus Primary Open-Angle Glaucoma
Coexistence of open-angle glaucoma and sarcoidosis-associated optic neuropathy
Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma
Association between glaucoma severity and driving cessation in subjects with primary open-angle glaucoma
Clinical Characteristics of Microcystic Macular Edema in Chronic Primary Angle-Closure Glaucoma and Primary Open-Angle Glaucoma Patients
Effect of Different Postures on Intraocular Pressure in Open-Angle Glaucoma
Diagnostic power of scleral spur length in primary open-angle glaucoma
Bilateral XEN Gel Stent Implantation in Juvenile-Onset Open-Angle Glaucoma
Amlodipine increases risk of primary open-angle glaucoma
Differences in optic nerve head structure between acute angle-closure glaucoma and open-angle glaucoma
Repeatability of selective laser trabeculoplasty for open-angle glaucoma
Genetic association of ANGPT2 with primary open-angle glaucoma
Uneventful Phacoemulsification after Trabeculectomy in Pseudoexfoliation Glaucoma versus Primary Open-Angle Glaucoma
Coexistence of open-angle glaucoma and sarcoidosis-associated optic neuropathy
Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma
Association between glaucoma severity and driving cessation in subjects with primary open-angle glaucoma
Clinical Characteristics of Microcystic Macular Edema in Chronic Primary Angle-Closure Glaucoma and Primary Open-Angle Glaucoma Patients
Effect of Different Postures on Intraocular Pressure in Open-Angle Glaucoma
Diagnostic power of scleral spur length in primary open-angle glaucoma
Bilateral XEN Gel Stent Implantation in Juvenile-Onset Open-Angle Glaucoma
Amlodipine increases risk of primary open-angle glaucoma
Differences in optic nerve head structure between acute angle-closure glaucoma and open-angle glaucoma
Repeatability of selective laser trabeculoplasty for open-angle glaucoma
Genetic association of ANGPT2 with primary open-angle glaucoma
Uneventful Phacoemulsification after Trabeculectomy in Pseudoexfoliation Glaucoma versus Primary Open-Angle Glaucoma
Coexistence of open-angle glaucoma and sarcoidosis-associated optic neuropathy
Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma
Association between glaucoma severity and driving cessation in subjects with primary open-angle glaucoma
Clinical Characteristics of Microcystic Macular Edema in Chronic Primary Angle-Closure Glaucoma and Primary Open-Angle Glaucoma Patients
Effect of Different Postures on Intraocular Pressure in Open-Angle Glaucoma
Diagnostic power of scleral spur length in primary open-angle glaucoma