Cell Penetrating Peptides: Classification, Mechanisms, Methods of Study, and Applications

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Abstract: Cell‐penetrating peptides (CPPs) encompass a class of peptides that possess the remarkable ability to cross cell membranes and deliver various types of cargoes, including drugs, nucleic acids, and proteins, into cells. For this reason, CPPs are largely investigated in drug delivery applications in the context of many diseases, such as cancer, diabetes, and genetic disorders. While sharing this functionality and some common structural features, such as a high content of positively charged amino acids, CPPs represent an extremely diverse group of elements, which can differentiate under many aspects. In this review, we summarize the most common characteristics of CPPs, introduce their main distinctive features, mechanistic aspects that drive their function, and outline the most widely used techniques for their structural and functional studies. We highlight current gaps and future perspectives in this field, which have the potential to significantly impact the future field of drug delivery and therapeutics.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Cell Penetrating Peptides: Classification, Mechanisms, Methods of Study, and Applications ; day:26 ; month:07 ; year:2023 ; extent:19
ChemMedChem ; (26.07.2023) (gesamt 19)

Creator: Gori, Alessandro
Lodigiani, Giulia
Colombarolli, Stella G.
Bergamaschi, Greta
Vitali, Alberto

DOI: 10.1002/cmdc.202300236

URN: urn:nbn:de:101:1-2023072615262942526660

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:44 AM CEST

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Gori, Alessandro
Lodigiani, Giulia
Colombarolli, Stella G.
Bergamaschi, Greta
Vitali, Alberto

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Cell Penetrating Peptides: Classification, Mechanisms, Methods of Study, and Applications

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Other Objects (12)

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